左旋精氨酸对肝缺血-再灌注损伤时血小板聚集功能的影响  

Effects of L-arginine on the function of platelet aggregation during hepatic ischemia/reperfusion injury

作　　者：王万铁[1] 林丽娜[2] 潘雪蓉[1] 徐正衸[1] 

机构地区：[1]温州医学院病理生理学教研室,325027 [2]温州医学院附属第一医院麻醉科

出　　处：《中国危重病急救医学》2004年第1期49-51,共3页Chinese Critical Care Medicine

基　　金：浙江省跨世纪学术和技术带头人基金资助项目(992086);温州市"551人才工程"培养基金资助项目(98113);浙江省卫生厅科研基金资助项目(98A087)

摘　　要：目的　探讨左旋精氨酸 (L Arg)对肝缺血再灌注损伤 (HIRI)时血小板聚集功能的影响。方法　选择 HIRI实验兔及肝癌手术患者 ,观察血小板最大聚集率 (Ptmax)、最大聚集时间 (Pt T)及聚集坡斜率(Pt S)的变化及 L Arg的调控作用。结果　实验动物和肝癌手术患者肝缺血再灌注期间 ,Ptmax和 Pt S均明显增加 (P<0 .0 5和 P<0 .0 1) ,Pt T均显著缩短 (P均 <0 .0 5 ) ;使用 L Arg后 ,上述指标的异常变化均显著减轻 ,其差异均有显著性意义 (P<0 .0 5和 P<0 .0 1)。结论　 L Arg对 HIRI时血小板聚集功能有明显的调控作用。Objective To explore the effects of L-arginine (L-Arg) on the function of platelet aggregation during hepatic ischemia-reperfusion injury(HIRI). Methods The changes in maximum aggregating rate of circulating platelets(Pt max), its maximum aggregating time(PtT) as well as its aggregating slopes(PtS) were measured. Effects of L-Arg on those parameters were observed during HIRI in 20 rabbits and 18 patients who were scheduled for elective hepatic surgery. Results Pt max and PtS all increased significantlly (P<0.05 and P<0.01), while PtT decreased remarkably(both P<0.05) during HIRI of rabbits and patients. After treatment with L-Arg, the abnormal changes of parameters as above were all alleviated remarkably (P<0.05 and P<0.01). Conclusion It is indicated that L-Arg can effectively regutate the function of platelet aggregation during HIRI.

关 键 词：缺血-再灌注损伤 肝脏 血小板聚集 左旋精氨酸 

分 类 号：R965[医药卫生—药理学]