血管紧张肽Ⅱ受体拮抗剂的药动学与临床用药  

Pharmacokinetics and reasonable clinical application of angiotensin Ⅱ receptor antagonist

作　　者：张瑾[1] 陈绍行[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海200025

出　　处：《中国新药与临床杂志》2004年第2期111-115,共5页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：血管紧张肽Ⅱ受体拮抗剂 (ARB)是一类在血管紧张肽Ⅱ 1型受体 (AT1受体 )水平拮抗血管紧张肽Ⅱ (ATⅡ )的降压药物。它们的药动学各具特色 ,因而具有不同的临床用药特点。氯沙坦 (losar tan)经细胞色素P 450 (CYP) 3A4及 2C9介导转化成其活性代谢物EXP31 74,故在肝功能不全时应减半量使用。替米沙坦 (telmisartan)的T1 / 2 最长 ,谷 /峰比最大 ,与地高辛合用时应动态监测地高辛血浓度 ,以免洋地黄中毒。由于ARB存在降压作用的平台反应 ,单一用药无法控制血压时 ,可联合应用利尿剂或钙拮抗剂。本文就ARB的药动学、降压治疗用药、联合用药 ,肝。Angiotensin Ⅱ receptor blocker (ARB) is a kind of antihypertensives, which can inhibit angiotensin Ⅱ at the level of the angiotensin Ⅱ AT1 receptor subtype. The six antihypertensives of ARB have different pharmacokinetical specialty so t hat they have different behavior in clinical application. With platform reaction of their antihypertensive effect, when the single one can not control the blood pressure, diuretics or calcium channel blockers can be used together. Their pha r macology, clinical applications and their interactions were reviewed in this pap er.

关 键 词：受体 血管紧张肽 药动学 抗高血压药 氯沙坦 缬沙坦 厄贝沙坦 替米沙坦 坎地沙坦 依普罗沙坦 血管紧张肽Ⅱ受体拮抗剂 

分 类 号：R972.4[医药卫生—药品] R544.1[医药卫生—药学]