老年哮喘患者中枢驱动力的变化  

The change of respiratory center drive in old-Age with asthma

作　　者：朱晓冬[1] 刘阳[1] 

机构地区：[1]天津医科大学总医院神经内科,天津300052

出　　处：《天津医科大学学报》2003年第4期494-497,共4页Journal of Tianjin Medical University

摘　　要：目的 :探讨老年哮喘患者呼吸中枢驱动力 (P0.1)的变化以及其对不同浓度CO2(4 % &8 %CO2)刺激时呼吸中枢驱动的变化和反应。方法 :应用西德耶格生产的呼吸中枢驱动检测仪(MasterScreen) ,检测老年哮喘患者静息态下和吸入不同浓度CO2(4% &8 %CO2)气状态下呼吸中枢驱动 (分别为P0.1、P0.1CO2A、P0.1CO2B)的变化。观察老年病哮喘患者二氧化碳刺激对其呼吸中枢驱动的影响。结果 :(1)40例老年哮喘患者P0.1 较正常对照组高且有显著性差异 (P<0.01) ,P0.1CO2A、P0.1CO2B均较正常对照组低 ,其中P0.1CO2B有显著差异 (P<0.05) ;FEV1.0(1s用力呼气量)、PEF(峰值呼气流速 )、较正常对照组明显减低 (P<0.05) ,鼻阻力正常 ,两组间无差异 (P>0.05)。(2)老年哮喘患者P0.1 与FEV1.0、PEF、R4Hz、R8Hz、R16Hz密切相关而与MIP、MEP、flr75、flr150、flr300无明显相关关系。结论 :上述结果与该类患者因通气功能障碍引起的低氧和二氧化碳潴留所致其对不同浓度二氧化碳刺激反应较正常人低有关。老年哮喘患者呼吸中枢驱动力 (P0.1)与呼吸功能指标FEV1.0、PEF和气道阻力指标R4Hz、R8Hz。Objective:To study the change of respiratory center drive(P 0.1 )and the response to stimulation of CO 2 (4%&8%CO 2 ).Methods:By Masterscreen to detect the P 0.1 during the asˉpiration of the air and the CO 2 (4%&8%CO 2 )in Old-Age with asthma.Results:In40patients with Old-Age asthma the P 0.1 was significantly higher than in the control(P<0.01).The P 0.1 CO 2 A and P 0.1 CO 2 B was significantly lower than the control,but the P 0.1 CO 2 B was signifiˉcantly different(P<0.05).The P 0.1 was correlated positively with FEV1.0?PEF?R4Hz?R8Hz?R16Hz.Conclusion:It is related with hypoxia and Carbon Dioxide retention due to dysfunction of ventilation that the P 0.1 is higher than the control but the P 0.1 CO 2 A and P 0.1 CO 2 B is lower than control in patients with Old-Age asthma.

关 键 词：哮喘 呼吸中枢驱动 呼吸功能 

分 类 号：R562.25[医药卫生—呼吸系统]