反复流产和不孕症与支原体和免疫因素的关系  

Association of mycoplasma and immune factors with recurrent spontaneous abortion and sterility

作　　者：赵晓岚[1] 楚雍烈[2] 叶国玲[1] 蔡晓宁[1] 刘琪[1] 

机构地区：[1]西安交通大学第二医院遗传研究室,陕西西安710004 [2]西安交通大学医学院病原生物学教研室,陕西西安710061

出　　处：《第四军医大学学报》2003年第20期1884-1886,共3页Journal of the Fourth Military Medical University

摘　　要：目的 :探讨反复自发性流产 (RSA)与支原体感染和抗心磷脂抗体 (ACA)之间的关系及不孕症与支原体感染和抗精子抗体 (ASA)之间的关系 .方法 :采用培养法分别对 338例RSA患者 (观察组 )和 2 4 8例不孕症患者 (观察组 )进行解脲支原体 (UU)和人型支原体 (MH)检测 ;采用ELISA法分别检测血清ACA IgM和ACA IgG(RSA观察组 )以及ASA IgM和ASA IgG(不孕症观察组 ) .同时分别选择 1 0 5例正常妇女作为对照组 .比较观察组和对照组各项指标阳性检出率 .结果 :RSA患者和不孕症患者支原体感染阳性率均高于对照组(P <0 .0 5 ) ;RSA患者血清ACA IgM阳性检出率明显高于对照组 (P <0 .0 5 ) ;不孕症观察组ASA IgM阳性检出率均显著高于对照组 (P <0 .0 5 ) ;RSA患者中 ,支原体感染阳性组ACA IgM ,ACA IgG以及ACA IgM +ACA IgG阳性率均明显高于支原体感染阴性组 (P <0 .0 5 ) ;不孕症患者中 ,支原体感染阳性组ASA IgM和ASA IgGA阳性率均明显高于支原体感染阴性组 (P <0 .0 5 ) .结论 :支原体感染是RSA和不孕症的原因之一 ;自身免疫性抗体与RSA和不孕症有一定关系 ;AIM: To elucidate the association of recurrent spontaneous abortion (RSA) with mycoplasma infection and anticardiolipin antibodies (ACA) , and the relationship of sterility to mycoplasma infection and antisperm antibodies (ASA). METHODS: Ureaplasma urealyticum (UU) and mycoplasma hominis (MH) from the cervical secretions were detected respectively by culture method in 338 women who had the history of recurrent spontaneous abortion three times or more and 248 sterile women, which were assigned as monitoring group, and 105 normal women, who did not have any miscarriage and delivered a live child as control group. Enzyme linked immunoassay (ELISA) was carried out to detect both isotypes of ACA and ASA , immunoglobulin M (IgM) and immunoglobulin G (IgG). The positivity rate of each index between 2 groups was compared. RESULTS: The positivity rates of UU and MH in monitoring group was significantly higher than that in control group ( P <0.05). The positivity rate of ACA IgM and ASA IgM in the monitoring group was significantly higher than that in the control group ( P <0.05). For RSA patients, the positivity rate of ACA IgM, ACA IgG andACA IgM+ACA IgG in UU or MH positive group was significantly higher than that in UU and MH in negative group ( P <0.05). For sterile women, the positivity rate of ASA IgM, ASA IgG in UU or MH positive group was significantly higher than that UU and MH in negative group ( P <0.05). CONCLUSION: It is suggested that UU or MH infection is closely correlated with RSA and infertility; RSA is correlated with ACA; sterility is correlated with ASA; both ACA and ASA are correlated with UU or MH infection.

关 键 词：流产 自发性 不孕 女(雌)性 尿素支原体 尿素分解:支原体人型 抗体 抗心脂 抗精子抗体 

分 类 号：R715.2[医药卫生—妇产科学]