甲磺酸加替沙星片和盐酸环丙沙星片随机对照治疗急性细菌感染  

Treatment of acute bacterial infection with Gatifloxacin mesylate and Cinrofloxacin: A randomized controlled trial

作　　者：吴昌归[1] 王汉民[2] 遆新宇[1] 刘颖格[1] 戴艳丽[1] 谭华[2] 

机构地区：[1]第四军医大学西京医院呼吸内科,陕西西安710033 [2]第四军医大学西京医院肾脏内科,陕西西安710033

出　　处：《第四军医大学学报》2003年第20期1908-1910,共3页Journal of the Fourth Military Medical University

摘　　要：目的 :评价甲磺酸加替沙星治疗急性细菌感染的有效性和安全性 .方法 :采用随机对照单盲临床试验的方法 ,完成实验药及对照药治疗急性细菌感染的临床试验 .结果 :甲磺酸加替沙星组与盐酸环丙沙星组的痊愈率分别为 78%(4 3/ 5 5 )和 72 % (38/ 5 3) ;有效率分别为 82 % (4 5 / 5 5 )和 77%(4 1 / 5 3) ,两组痊愈率和有效率无统计学显著差异 (P >0 .0 5 ) .结论 :甲磺酸加替沙星对急性细菌感染有很好的临床疗效和微生物学效果 ,耐受性和安全性好 ,不失为敏感菌感染可选药物 .AIM: To study the efficacy and safety of gatifloxacin mesylate on acute bacterial infection. METHODS: A randomized control clinical trial was performed. Forty patients were randomly divided into two groups, receiving gatifloxacin mesilate and cinrofloxacin respectively. Each subject was given 5 or 7 days treatment. RESULTS: The total cure rate of gatifloxacin mesylate and cinrofloxacin was 78 %(43/55) and 72% (38/53) and the total effective rate 82% (45/55) and 77% (41/53) respectively. There was no significant difference in the efficacy between gatifloxacin mesylate and cinrofloxacin ( P >0.05). CONCLUSION: Gatifloxacin was an effective drug to cure acute bacterial infection.

关 键 词：甲磺酸加替沙星 环丙沙星 急性细菌感染 

分 类 号：R978.1[医药卫生—药品]