简便GnRH激发试验对中枢性性早熟的诊断  

A more simplified gonadotropin-releasing hormone test for central precious puberty

作　　者：王栋钢[1] 雷培芸[1] 杨咏梅[2] 杨渝生[1] 尹僖[1] 

机构地区：[1]重庆医科大学儿童医院核医学科,重庆400014 [2]重庆市巴南区第二人民医院

出　　处：《山西医科大学学报》2003年第6期561-563,共3页Journal of Shanxi Medical University

摘　　要：目的　探讨简便的促性腺激素释放激素 (GnRH)激发试验诊断中枢性性早熟 (CPP)的有效方法。方法　运用回顾性临床研究的方法 ,对CPP和外周性性早熟 (PPP)各 139例女童于晨 8时空腹作传统GnRH激发试验 ,静脉滴注戈那瑞林 0 2 5μg/kg和生理盐水 10ml,分别于滴注后 0、30、6 0和 90min各抽静脉血 1次 ,运用放射免疫分析测定各时点血清促滤泡生成素(FSH)、黄体释放激素 (LH) ,并用等效检验比较传统和简便的GnRH激发试验的结果。结果　简便与传统GnRH激发试验LH平均峰值在CPP组均为 ( 2 4 .93± 1.89)U/L ,可检出总例数均为 139例。而在PPP组分别为 ( 2 .2 4± 0 .19)和 ( 2 2 3±0 16 )U/L ,可检出总例数分别为 133和 139例 ,经等价检验 ,简易与传统GnRH激发试验无显著性差异 (P <0 .0 5 )。结论　GnRH激发试验只作戈那瑞林滴注后 0、30和 6 0min的检查 ,可省去滴注后 90min的检查。Objective To study a more simplified method for testing the gonadotropin releasing hormone (GnRH) in central precious puberty (CPP) . Methods Using the method of retrospective clinical study: children with CPP and ones with peripheral precocious puberty (CPP) (each n =139) underwent the traditional gonadotropin stimulating test at 8:00 in fasting, and were given gonadorelin 0.25 μg/kg within 15 min by intravenous drop, and the serum FSH and LH levels were detected by radioimmunoassay at min 0,30,60 and 90, respectively. The results were compared. Results For LH the GnRH peak value in simplified and traditional tests was (24.93±1.89) U/L in all 139 children, while for PPP children it was (2.24±0.191) U/L and (2.23±0.16) U/L in 133 children and 139 ones, respectively. There was no significant difference between simplified and traditional tests for GnRH ( P <0 05). Conclusion The GnRH stimulating test can be used for testing LH and FSH at min 0, 30 and 60 after giving gonadorelin, abridging the test at min 90.

关 键 词：GnRH激发试验 中枢性性早熟 诊断 滤泡刺激素 促性腺素释放激素 儿童 

分 类 号：R725.8[医药卫生—儿科]