3-取代和3,4-二取代噻吩的合成与表征  

Synthesis and Characterization of 3-Substituted and 3,4-Disubstituted Thiophenes

作　　者：佟拉嘎[1] 蹇锡高[1] 王锦艳[1] 于艳[1] 

机构地区：[1]大连理工大学高分子材料系,大连116012

出　　处：《有机化学》2004年第1期67-70,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金 (No.50 1 4 30 1 3)资助项目

摘　　要：以噻吩、48 % (m/m)氢溴酸水溶液、3 5 % (m/m)过氧化氢水溶液、高纯氨、金属钠为原料合成了 3 溴噻吩和 3 ,4 二溴噻吩 ,3 溴噻吩和 3 ,4 二溴噻吩分别以 (dppp)NiCl2 为催化剂合成了 3 烷基噻吩和 3 ,4 二烷基噻吩 .3 溴噻吩以CuI ,NaHSO4为催化剂合成了 3 烷氧基噻吩 ,产率较高 .并用核磁共振谱。3-Bromothiophene and 3,4-dibromothiophene were synthesized in high yields from thiophene, 48% (m/m) aqueous hydrobromic acid, 35% (m/m) aqueous hydrogen peroxide solution, anhydrous liquid ammonia and sodium. In the presence of (dppp)NiCl 2, 3-bromothiophene and 3,4-dibromothiophene reacted with Grignard reagents to afford 3-alkylthiophene and 3,4-dialkylthiophene in good yields, respectively. 3-Alkoxythiophene was synthesized from 3-bromothiophene and alcohol using CuI and anhydrous sodium bisulfate as catalysts. The compounds obtained were characterized by 1H NMR, MS spectra and elemental analysis.

关 键 词：3—烷基噻吩 3 4—二烷基噻吩 3—溴噻吩 3 4—二溴噻吩 3—烷氧基噻吩 合成 结构表征 噻吩衍生物 

分 类 号：O626[理学—有机化学]