气态甲醛对人体颊黏膜细胞遗传毒性的研究  

Studies on genotoxicity of gaseous formaldehyde on human buccal cells.

作　　者：鲁志松[1] 严彦[1] 乔琰[1] 姚汉超[1] 杨旭[1] 

机构地区：[1]华中师范大学生命科学学院,湖北武汉430079

出　　处：《中国环境科学》2003年第6期566-569,共4页China Environmental Science

基　　金：国家"十五"科技攻关课题(2001BA704B01)

摘　　要：以人体颊黏膜细胞作为实验材料,以彗星实验为终点效应,采用仿真式的气体灌流进行体外实验,对气态甲醛遗传毒性进行了探讨.结果显示气态甲醛染毒1h,甲醛在0.5mg/m3和1.0mg/m3时具有断裂作用,在3.0mg/m3时则具有明显交联作用.这表明气态甲醛的遗传毒性在高浓度(3.0mg/m3)时可能会提高癌症发生的几率.Taking human buccal cells as testing material to study genotoxicity of gaseous formaldehyde with comet test as destination effect, and adopting gas pouring flow of imitation type for the test in vitro. At 0.5mg/m3 and 1.0mg/m3 formaldehyde possesses breaking action when it has been toxicity-contaminated for 1h; and at 3.0mg/m3 possesses obvious cross-link action. This indicates that formaldehyde could increase the possibility of cancer at high levels.

关 键 词：气态甲醛 遗传毒性 人体颊黏膜细胞 彗星实验 体外实验 

分 类 号：R994.6[医药卫生—毒理学]