应用ROC曲线评价心肌钙蛋白T在急性心肌梗死诊断中的临床准确性  

Assessment of receiver operator character curve on the diagnostic value of cardiac troponin T in acute myocardial infarction

作　　者：孙虹[1] 孙鷖[1] 台虹[1] 肖质[1] 牛华[1] 赵崇吉[1] 

机构地区：[1]云南省临床检验中心,云南昆明650032

出　　处：《检验医学》2004年第1期30-32,共3页Laboratory Medicine

摘　　要：目的　应用临床诊断性能 (ROC)曲线评价心肌钙蛋白T(cTnT)在急性心肌梗死 (AMI)诊断中的临床准确性。方法　电化学发光免疫分析法测定病例组及健康对照组的血清cTnT ,所得数据用ROC曲线统计软件进行分析。结果　cTnT在AMI诊断中的ROC曲线图左上方最高点为 0 .0 4 μg/L ,其诊断敏感度 91% ,特异度92 %。结论　cTnT在AMI诊断中的最佳临界值为 0 .0 4 μg/L ,比生产厂商提供的诊断临界值 0 .1μg/L低 ,故生产厂商提供的诊断临界值只能作为参考 ,各临床实验室应根据各自的方法学 。Objective To estimate the clinical accuracy of cardiac troponin T(cTnT) in the diagnosis of acute myocardial infarction(AMI) by using the receiver operating character(ROC) curve. Methods Determining the cTnT in AMI patients and in control group by ELECSYS immunoassay system, then analyzing the data with ROC curve statistical software. Results At the peak point of the ROC curve the cTnT was 0.04 μg/L in AMI, which generated a diagnostic sensitivity of 91% and a specificity of 92%. Conclusions The best diagnostic cut off point of cTnT in our laboratory is 0.04 μg/L, which is much lower than the cut off point 0.1 μg/L of ELECSYS manufacturer. So each clinical laboratory should decide their own cut off points in the diagnosis of AMI which adapted to their own methods.

关 键 词：ROC曲线 评价 心肌钙蛋白T 急性心肌梗死 诊断 临床准确性 

分 类 号：R542.22[医药卫生—心血管疾病] R446.1[医药卫生—内科学]