二维斑点追踪技术评价野百合碱诱导肺动脉高压大鼠的右心室整体与局部功能随时间的动态变化  

Dynamical Evaluation of Right Ventricular Function of Rats with Pulmonary Arterial Hypertension Caused by Monocrotaline Using 2D Speckle Tracking Imaging

作　　者：王红鹄[1] 杨军[1] 白洋[1] 王旭[1] 韩舒[1] 陈玲[2] 

机构地区：[1]中国医科大学附属第一医院心血管超声科,沈阳市110001 [2]中国医科大学附属第一医院老年医学科,沈阳市110001

出　　处：《中国超声医学杂志》2015年第3期257-259,共3页Chinese Journal of Ultrasound in Medicine

基　　金：高等学校博士学科点专项科研基金(No.20112104110010)

摘　　要：目的应用二维斑点追踪(2D-STI)技术定量评价实验性肺动脉高压(PAH)大鼠右心功能的动态变化,探讨肺动脉高压早期无创性评价右心功能的灵敏指标。方法 Sprague-Dawley(SD)Rat大鼠40只,分5组。造模成型后进行超声心动图检查。检查完毕后经右心室导管测压,取出心脏称重。应用2D-STI技术分节段评价右心室游离壁及室间隔基底段、中间段应变、应变率。结果实验组与对照组相比较,右心室侧壁中间段收缩期峰值应变率从3周起开始减低,差异有统计学意义。结论 2D-STI技术通过分析右心室应变率早期发现及动态观察PAH大鼠右心室心肌重构与功能的变化。Objective To evaluate the dynamical variations of right ventricular function of rats with pulmonary arterial hypertension(PAH)using two dimensional speckle tracking imaging(2D-STI),and noninvasively evaluate the sensitive indexes of right ventricular function with PAH in early stages.Methods Forty male SD rats were randomly divided into five groups.Echocardiographic scan were preformed in each group at specified time.Then pulmonary arterial pressure was measured by right heart catheterization.Routine echocardiographic data,peak strain and peak strain rate of right ventricule were analyzed at EchoPac workstation.Results Compared with the normal group,peak strain rate at systolic stage of middle section of right ventricular apical wall was decreasing after three weeks.Conclusions2D-STI can be used to assess the peak strain and peak strain rate of right ventricule.The remodeling and function of right ventricule of rats with PAH can also be early detected and dynamically observed.

关 键 词：超声心动图描记术 斑点追踪显像 肺动脉高压 右心室功能 大鼠 

分 类 号：R445.1[医药卫生—影像医学与核医学] R544.1[医药卫生—诊断学]