系统性红斑狼疮患者颈动脉内中膜厚度与血清高敏CRP的关系  

Relationship of Carotid Intima-media Thickness and Hs-CRP in Patients with Systemic Lupus Erythematosus

作　　者：杨景阳[1] 吕国荣 张东妹[1] 李拾林[1] 

机构地区：[1]福建医科大学附属第二医院彩超室,福建省泉州市362000 [2]泉州医学高等专科学校

出　　处：《中国超声医学杂志》2015年第3期265-267,共3页Chinese Journal of Ultrasound in Medicine

摘　　要：目的探讨系统性红斑狼疮(SLE)患者颈动脉内中膜厚度(IMT)、外周血高敏C反应蛋白(hs-CRP)的表达水平及两者相关性。方法超声检查70例SLE女性患者(IMT≥1.0mm者12例为IMT阳性组;IMT<1.0mm者58例为IMT阴性组)及40例健康女性的颈动脉IMT,并用ELISA测定其血清hs-CRP水平,分析两者相关性。结果 (1)SLE组(包括IMT阳性组及IMT阴性组)hs-CRP水平高于对照组(P<0.05),IMT阳性组hs-CRP水平高于IMT阴性组(P<0.05);(2)SLE组IMT与病程及hs-CRP水平呈正相关(分别为r=0.743,P<0.001及r=0.827,P<0.001);(3)根据ROC曲线,当hs-CRP在4.44mg/L时诊断指数最大(0.815),灵敏度和特异度分别为91.7%和89.8%。结论颈动脉IMT联合hs-CRP检测可作为SLE患者早期动脉粥样硬化的一项预测方法。Objective To investigate carotid intima-media thickness(IMT)and serum high sensitive C-reactive protein(hs-CRP)levels in patients with systemic lupus erythematosus(SLE)and their relationship.Methods Carotid IMT were measured by ultrasound and serum hs-CRP levels were measured by ELISA in 70 SLE patients(IMT≥1.0mm were 12 cases of IMT positive group;IMT <1.0mm were 58 cases of IMT negative group)and 40 healthy controls.Results(1)Hs-CRP levels were higher in SLE group(include IMT positive and negative group)than control group(P<0.05),hs-CRP levels were higher in IMT positive group than in IMT negative group(P<0.05).(2)IMT in SLE group was positively correlated with duration of disease and hs-CRP levels(respectively r=0.743,P<0.001 and r=0.827,P<0.001).(3)The diagnosis efficiency of the hs-CRP assay at the level 4.44mg/L determined in ROC curve with controls having benign diseases and healthy women group had the most significant diagnostic index(0.815),with a sensitivity of 91.7%and a specificity of 89.8%.Conclusions Detection of carotid IMT combined serum hs-CRP levels can be used as a prediction method of early atherosclerosis in patients with SLE.

关 键 词：系统性红斑狼疮 超声 颈动脉内中膜厚度 高敏 C反应蛋白 动脉粥样硬化 

分 类 号：R445.1[医药卫生—影像医学与核医学] R593.241[医药卫生—诊断学]