高频超声对透析患者肱动脉与腘动脉血管内皮舒张功能的对比研究  

Flow Mediated Dilation of Brachial Artery and Popliteal Artery in Hemodialysis Patients Using Ultrasound:a Comparative Study

作　　者：李翔[1] 徐岩[2] 王正滨[1] 

机构地区：[1]青岛大学附属医院超声科,青岛市266003 [2]青岛大学附属医院肾内科,青岛市266003

出　　处：《中国超声医学杂志》2015年第3期280-283,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的探讨超声比较血液透析患者肱动脉与腘动脉血管内皮舒张功能的差异性。方法分别选择健康志愿者(NC组),尿毒症非血液透析患者(Pre-HD组)和透析满12个月患者(透析12个月组),利用彩色多普勒超声测量肱动脉与腘动脉血管基础状态及加压后血管内径和峰值速度,并计算血流介导的扩张值(FMD)。比较肱动脉与腘动脉FMD及峰值流速的差异。结果肱动脉FMD(%)、腘动脉FMD(%)、NC组、Pre-HD组、透析12个月组显著性减少(P<0.05);肱动脉与腘动脉FMD(%)比较NC组、Pre-HD组、透析12个月组显著性减少(P<0.05);肱动脉与腘动脉FMD差值(%),NC组、PreHD组、透析12个月组显著性增加(P<0.05)。结论血液透析患者血管内皮舒张功能障碍重于非透析患者,且腘动脉血管内皮舒张功能障碍进展速度大于肱动脉。Objective To study the difference of vascular endothelial function by evaluating flow mediated dilation(FMD)of brachial artery and popliteal artery in hemodialysis patients with ultrasound.Methods Vascular diameter and velocity in baseline and after reactive hyperaemia of brachial artery and popliteal artery were detected with high frequency ultrasound in healthy volunteers,predialysis patients(Pre-HD)and patients with 12 months,FMD were calculated and compared among the 3groups.Results Difference of brachial artery FMD and popliteal artery FMD between each two groups were significant(P<0.05).Difference of FMD between brachial artery and popliteal artery in each groups were significant(P<0.05).The difference between each two groups of brachial artery and popliteal artery FMD were significant(P<0.05).Conclusions With hemodialysis,endothelial dysfunction of popliteal artery progress faster than brachial artery.

关 键 词：血液透析 肱动脉 超声检查 腘动脉 

分 类 号：R445.1[医药卫生—影像医学与核医学] R459.5[医药卫生—诊断学]