干扰素新制剂的应用研究  

Applied Study of New Preparations of Interferon

作　　者：朱健平[1] 

机构地区：[1]广东医学院药理学教研室,广东湛江524023

出　　处：《中国药业》2004年第1期39-41,共3页China Pharmaceuticals

摘　　要：目的:对近年来干扰素新制剂的应用研究进行综述。方法:检索文献资料,对干扰素的长效制剂、靶向制剂、控释和缓释制剂等新制剂的特点和临床应用进行分析。结果:不同的新制剂可改变干扰素的生物利用度,延长其生物半衰期,实现体内靶向给药,提高病灶局部药物浓度,提高疗效和减少不良反应。结论:新制剂的研制为干扰素的临床应用开辟了更为广阔的领域。Objective: Recent applied study of new preparations of inlerferon was reviewed. Methods: To collect medical literatures in recent years at home and abroad. The trait and clinical application of new preparations of interferon were analyzed. Results: Different new preparations can change bioavailabilily of interferon and its biologic half-life time. Its distribution patterns in tissues were changed and they had a stronger effect and may decrease its adverse reaction. Conclusion: For clinical application of interferon, study of new preparation inaugurates a wide prospect.

关 键 词：干扰素 长效制剂 靶向制剂 缓释制剂 控释制剂 

分 类 号：R978.7[医药卫生—药品] R979.1[医药卫生—药学]