DNA芯片技术在新兽药开发中的应用现状与展望  

The present application and prospect of DNA chip technology in new veterinary medicine development

作　　者：李远森[1] 马志杰[1] 田淑琴[1] 

机构地区：[1]西南民族大学药理教研室,成都610041

出　　处：《西南民族大学学报（自然科学版）》2003年第3期360-362,共3页Journal of Southwest Minzu University(Natural Science Edition)

摘　　要：DNA芯片是指被包在固相载体上有序排列的高密度DNA微点阵,它具有微型微量化、多样性、大规模、高度并行化和高度自动化这五大特点,从DNA芯片分化而成的cDNA芯片可以用来检测未知化合物的药效和毒理学参数。结合我国新兽药开发的现状和存在的问题,说明了我国应用DNA芯片技术开发新兽药的可行性和必要性,并对应用DNA芯片技术开发新兽药的未来前景作了展望。DNA chip is defined as the high-density DNA microarrays orderly covering the solid carrier and features miniature, diversification, high capacity, high parallelization and high automation. Deriving from the DNA chip, cDNA can be used to examine the medical effect of unknown compound and the parameter of toxicology. Based on the present conditions and exiting problems of new veterinary medicine development in China, this article illustrates the feasibility and necessity for application of DNA chip technology in developing new veterinary medicine and previews the prospect of application of DNA chip technology in developing new veterinary medicine in China.

关 键 词：DNA芯片 兽药 生物芯片 药物开发 工作原理 

分 类 号：S859[农业科学—临床兽医学] Q5[农业科学—兽医学]