自发性高血压大鼠左心室流出道自发性电活动的特征  

The Feature of Spontaneous Action Potential of Aortic Vestibul on Spontaneously Hypertensive rats

作　　者：邱丽颖[1] 焦宏[1] 吕莉[1] 马建伟[1] 

机构地区：[1]张家口医学院生理教研室,河北张家口075000

出　　处：《高血压杂志》2003年第2期158-160,共3页Chinese Journal of Hypertension

基　　金：河北省卫生厅资助项目:No:990 1 5;河北省自然科学基金资助项目:No:30 0 379

摘　　要：利用玻璃微电极细胞内记录方法 ,记录了自发性高血压大鼠 (SHR)和Wistar鼠左心室流出道自发性慢电位和自发性快电位的特征。结果发现 ,SHR自发性快电位的动作电位时程 (APD)、复极至 5 0 %时间 (APD50 )和复极至 90 %的时间 (APD90 )均明显长于Wistar鼠 (P <0 0 1) ;SHR的自发放电频率 (RPF)明显慢于Wistar鼠 (P <0 0 5 )。结果提示 :SHR左心室流出道自发性的快电位和慢电位均表现为APD、APD50 和APD90 的延长 。Spontaneous action potential in aortic vestibule of spontaneously hypertensive rats heart were intracellularlly recorded. Electrophysiological parameters examined are: resting potential (RP), amplitude of action potential (APA), maximal rate of depolarization of phase 0 (Vmax), duration of 50% and 90% repolarization (APD 50 and APD 90 ) and rate of automatic pacemaker firing (RPF). It was found that (1) the APD, APD 50 and APD 90 of the SHR were prolonged on both fast and slow spontaneous action potential, and (2) the RPF of SHR was decreased. The results suggested that the APD, APD 50 and APD90 were prolonged, and the RPF was decreased in aortic vestibule of SHR.

关 键 词：自发性高血压大鼠 左心室流出道 自发电活动 

分 类 号：R544.1[医药卫生—心血管疾病] R318.03[医药卫生—内科学]