原发性高血压患者颈动脉形态学及血流动力学的变化  

Change of carotid morphology and hemodynamics in patients with essential hypertension

作　　者：王菁哲[1] 余转 魏静[1] 张婧[1] 薛玉[1] 陈宝定[1] 

机构地区：[1]江苏大学附属医院超声医学科,江苏镇江212001

出　　处：《江苏大学学报（医学版）》2015年第4期339-341,共3页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:通过彩色多普勒超声检测原发性高血压(essential hypertension,EH)患者颈动脉血管形态学及血流动力学相关指标,探究EH与颈动脉硬化(carotid atherosclerosis,CAS)的关系。方法:选取于我院就诊的48例高血压患者为观察组,并与同期62例健康体检者进行对照。多普勒超声检查两组研究对象的颈动脉内径(D)、内-中膜厚度(IMT)、直径狭窄率(D')、收缩期峰值流速(PSV)、舒张末期流速(EDV)、PSV/EDV、阻力指数、搏动指数,计算最大剪切率(SR)和两组患者斑块检出率。利用SPSS 19.0软件包对上述数据进行统计分析。结果:观察组患者的D、IMT、D'、PSV/EDV、阻力指数、搏动指数均明显高于对照组,PSV、EDV、SR明显低于对照组,同时观察组较对照组斑块检出率明显增高,差异均有统计学意义(P<0.05)。结论:原发性高血压易影响颈动脉血管形态和血流动力学,是颈动脉硬化的重要危险因素。在颈动脉硬化进程中,高血压通过高、低剪切力的协同作用发挥效应。Objective: To explore the relationship between essential hypertension( EH) and carotid atherosclerosis,observing carotid artery morphological and hemodynamic condition by color Doppler ultrasound in patients with EH. Methods: A total of 48 hypertensive patients were selected as the observation group and 62 healthy volunteers during the corresponding time in our hospital for medical examination were as the control group. Doppler ultrasound was used to measure every patient’s carotid artery diameter( D),insidemedia thickness( IMT),diameter stenosis rate( D’),peak systolic velocity( PSV),end-diastolic velocity( EDV),peak systolic velocity /end-diastolic velocity( PSV/EDV),resistance index and pulsatility index;and calculate the maximum shear rate( SR) and plaque detection rate of each group. Finally these data were analyzed by SPSS 19. 0 software package. Results: Obviously,the observation group’s D,IMT,D’,PSV / EDV,resistance index and pulsatility index were higher,while PSV,EDV and SR were lower than the control group. Besides,the plaque detection rate of the observation group was also markedly higher than the control group. All of these differences were statistically significant( P < 0. 05). Conclusion: EH is likely to affect the carotid vascular morphology and hemodynamics and is an independent risk factor in the carotid atherosclerosis. In the process of carotid atherosclerosis,hypertension plays an important role in the carotid artery by the synergistic effect of high and low shear.

关 键 词：原发性高血压 颈动脉硬化 颈动脉超声 

分 类 号：R544.11[医药卫生—心血管疾病]