香砂平胃散对小鼠胃排空的影响  

Effect of Xiangsha Pingweisan on gastric emptying motility in mice

作　　者：王学清[1] 王秀杰[2] 李岩[1] 

机构地区：[1]中国医科大学附属二院消化内科,辽宁省沈阳市110004 [2]沈阳市第五医院内科,辽宁省沈阳市110023

出　　处：《世界华人消化杂志》2003年第5期571-574,共4页World Chinese Journal of Digestology

摘　　要：目的:研究香砂平胃散及其组成药物对胃排空功能的影响.方法:以葡聚糖蓝(BD)2000为标记物,观察小鼠的胃内色素残留量.结果:香砂平胃散组[(39.5±18.3)%]及西沙必利组[(36.97±16.4)%]的胃残留率与对照组[(100.0±24.2)%]比较差异有显著性(P<0.05),两组之间无显著性差异(P>0.05).正交分析表明苍术、陈皮、木香、砂仁有促进胃排空作用,各味药物之间存在广泛的协同作用.厚朴、木香和砂仁的促胃排空作用与香砂平胃散无显著性差异(P>0.05).结论:香砂平胃散及其部分组成药物有促胃排空作用,苍术、木香、砂仁、陈皮起主要作用,各组成药物之间存在着广泛的一级交互作用.AIM:To evaluate the effects of Chinese herbs Xiangsha Pingweisan (XSPWS) decoction and its component on gastric emptying in healthy mice. METHODS:Mice were randomly divided into control group, cisapride group and XSPWS group. The effects of XSPWS on gastric emptying were investigated in vivo by measuring gastric remainder rates of Blue Dextron (BD) 2000. Additionally, the effect of each component herb in XSPWS recipe was evaluated in the same way according to orthogonal design. RESULTS:Compared with control group (100.0±24.2) %, the rates of gastric remainder in XSPWS group (39.5±18.3) % and cisapride group (36.9±16.4) % were all significantly decreased (P <0.05). There were no significant difference between XSPWS group and cisapride group (P >0.05). Except radix glycyrrhizae preparta group, the gastric emptying rates of other component herbal groups were significantly higher than that of control group (P <0.01). Based on the analysis of orthogonal design, there were wide–ranging first–grade mutual roles within the six component herbs. CONCLUSION:XSPWS and its some component herbs can accelerate the gastric emptying in mice in vito significantly. There are wide–ranging first–grade mutual roles within the six component herbs.

关 键 词：香砂平胃散 小鼠 胃排空功能 胃动力障碍 功能性消化不良 中医药疗法 

分 类 号：R285.5[医药卫生—中药学]