吗啡依赖大鼠戒断后的觅药行为与前脑区Fos表达  

Morphine preference following prolonged abstinence associated Fos expression in the forebrain

作　　者：梁秦川[1] 高国栋[1] 熊华[2] 王庆丰[1] 

机构地区：[1]唐都医院神经外科 [2]流行病学教研室,陕西西安710038

出　　处：《医学研究生学报》2003年第10期736-739,共4页Journal of Medical Postgraduates

基　　金：军队临床高新技术重大项目基金资助课题 (批准号 :2 0 0 2 18)

摘　　要：目的 :研究吗啡依赖大鼠长期停药后的觅药行为和前脑区Fos蛋白表达。　方法 :大鼠皮下注射吗啡使其成瘾 ,停药 35天后进行条件性地点偏爱实验 (CPP) ,并检测前脑区域Fos蛋白表达。　结果 :慢性吗啡处理组大鼠的地点偏爱明显强于对照组 ,在扣带回前区 (Cg)、伏隔核 (NAc)、终纹床核腹外侧 (BNST VL)、杏仁核核心部(ACE)和基底外侧部 (ABL)的Fos蛋白表达显著高于对照组。　结论 :地点偏爱行为与吗啡相关环境暗示引起的前脑区激活有关 ,预先吗啡处理可影响这种关系。Objectives: To observe the drug seeking behavior in chronically morphine pretreated, abstinent rats and determine brain regions involved in this behavior. Methods: Preferences for morphine associated environments and Fos expression in some brain regions were measured 35 days after withdrawal of chronic morphine treatment. Results: The preference for the morphine environment was greatly increased by morphine pretreatment. The conditioned morphine pretreated group showed significantly higher Fos levels than either the conditioned or non conditioned control groups in the Cg, Ac C, BNST VL, ACE and ABL. Conclusions: A relationship between place preference behavior and neural indices of activation exist in the forebrain in response to morphine conditioned cues, which may be chronically modulated by prior morphine exposure.

关 键 词：吗啡依赖 c-Fos 杏仁核 扣带回 终纹床核 伏隔核 

分 类 号：Q189[生物学—神经生物学]