冠状动脉介入治疗对组织因子途径抑制物的影响  

Effect of Percutaneous Coronary Intervention on Plasma Tissue Factor Pathway Inhibitor

作　　者：刘启明[1] 陈琳[1] 周胜华[1] 沈向前[1] 祁述善[1] 

机构地区：[1]中南大学湘雅二医院心内科,湖南长沙410011

出　　处：《中国医师杂志》2003年第7期868-869,871,共3页Journal of Chinese Physician

基　　金：卫生部杰出青年科研基金资助项目 (980 7)

摘　　要：目的　探讨冠状动脉介入治疗对冠心病患者冠脉循环前后组织因子途径抑制物 (TFPI)的影响。方法　用酶联免疫吸附法 (ELISA)检测 42例冠心病患者经皮冠状动脉球囊成形和 /或支架植入术前、术后冠状静脉窦 (CS)和冠状动脉窦 (CA)血浆TFPI含量 ,同时发色底物法测定其活性。结果　冠脉介入治疗术前冠状静脉窦比冠状动脉窦血浆TFPI含量明显升高 (P <0 0 5 ) ,但术后冠状静脉窦与冠状动脉窦血浆TFPI活性比较无显著性差异 (P >0 0 5 ) ;术后冠状静脉窦和冠状动脉窦血浆TFPI含量与活性均较其术前明显升高 ( P <0 0 5 )。结论　冠心病患者冠脉循环后血浆TFPI含量升高 ,冠脉介入治疗术后其含量与活性明显增加 ,TF PI发挥抗凝。Objective To determine the levels and activities of tissue factor pathway inhibitor(TFPI) in patients with coronary heart disease(CHD) by percutaneous coronary intervention(PCI).Methods The plasma levels of TFPI were measured by enzyme-linked immunosorbent assay(ELISA), and the activities of TFPI were measured by chromogenic assay in coronary vein sinus(CS) and coronary artery sinus(CA) before and after percutaneous transluminal coronary angioplasty(PTCA) and/or stenting in 42 patients with CHD respectively.Results The plasma levels of TFPI were increased significantly in CS than that in CA before PCI (P<0 05).However, there were no significantly difference in plasma TFPI levels between in CS and CA after PCI(P>0 05). After PCI,the plasma levels and activities of TFPI were higher significantly in CS and CA than before PCI(Both P<0 05).Conclusions In CHD, the levels of TFPI in the plasma of CS were increased significantly,TFPI was higher significantly after PCI, and it could play an important role in aspects of anticoagulation and antithrombosis.

关 键 词：冠心病 经皮冠状动脉球囊成形术 支架植入术 组织因子途径抑制物 冠状动脉介入治疗 

分 类 号：R541.4[医药卫生—心血管疾病]