人巨细胞病毒感染致内皮功能异常在急性冠脉综合征发病中的作用  

Human Cytomegalovirus Infection Leading to Endothelial Function Disorder and Its Possible Role in Acute Coronary Syndrome Pathogenesis

作　　者：欧阳定安[1] 王朝晖[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院,湖北武汉430022

出　　处：《中国医师杂志》2003年第7期899-901,共3页Journal of Chinese Physician

摘　　要：目的　探讨人巨细胞病毒 (HCMV)感染致内皮功能异常与冠心病 (CHD)的关系及其在急性冠脉综合征发病中的作用。方法　对CHD组 ( 5 9例 )包括急性冠脉综合征 (ACS)患者 (A组 ,3 5例 )和症状稳定者 (B组 ,2 4例 ) ,非CHD组患者 (对照组 ,2 7例 )进行外周血HCMV -DNA、IgM、IgG和内皮素 (ET)、可溶性细胞间粘附分子 (sICAM )检测。结果　⑴在CHD组HCMV -DNA、IgM、IgG阳性率与非CHD组间差异有显著性 (P <0 0 5 ) ,特别是A组与非CHD组差异有非常显著性 (P <0 0 1)。⑵ET、sICAM均值在CHD组 ,特别是A组与非CHD组间差异有显著性 (分别P <0 0 5或 <0 0 1)。结论　HCMV感染致内皮功能异常与CHD及ACS发病密切相关 ;ET、sICAM升高在CHD ,特别是ACS的发生和发展中起重要作用。Objective To study the relationship between HCMV infection and endothelial function disorder and its possible role in CHD and acute coronary syndrome (ACS).Method HCMV-DNA, IgM, IgG, ET, sICAM were detected in 59 patients with CHD(CHD group) and 27 patients without CHD(non-CHD group ). The CHD group was divided into acute coronary syndrome group (group A,n=35) and stable symptom group (group B,n=24).Results The positive rate of HCMV-DNA, IgM, IgG was higher in CHD group, especially in group A than that in non-CHD group (P<0 05, P<0 01 separately). The levels of ET, sICAM also were higher in CHD group, especially in group A(P<0 05,P<0 01 respectively).Conclusions HCMV infection leading to injury of the vascular endothelium is related to CHD,especially to ACS pathogenesis.The increase of ET, sICAM level play an important role in the process of CHD development, especially in ACS.

关 键 词：冠心病 急性冠脉综合征 人巨细胞病毒 内皮功能异常 内皮素-1 细胞间粘附分子-1 发病机制 

分 类 号：R541.4[医药卫生—心血管疾病]