抗柯萨奇病毒B病毒性心肌炎胶囊复方提取物对病毒性心肌炎小鼠心肌的保护作用  

The myocardial protection about viral myocarditis mice by compound extracting from againsting coxsackie virus B viral myocarditis capsule

作　　者：林清[1] 马会霞[1] 高秀娟[1] 谢飞[1] 徐静[1] 王巍[1] 包巨太[1] 

机构地区：[1]河北联合大学中医学院,河北唐山063000

出　　处：《中国老年学杂志》2015年第6期1609-1611,共3页Chinese Journal of Gerontology

基　　金：国家"十一五"规划科技重大专项课题(2009ZX09103-442);河北省科技厅项目(101Z6426P);河北省中医药管理局项目(2013177)

摘　　要：目的探讨抗柯萨奇病毒B病毒性心肌炎胶囊(K-Cox B-JN)复方提取物对于阿霉素(ADM)诱导小鼠心肌损伤模型的保护作用。方法将复方提取物分为不同组别,观察其对心肌组织病理、小鼠心脾指数、小鼠血清肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(c Tn I)的影响。结果 K-Cox B-JN复方总黄酮低、中、高三组、黄酮+皂苷及水提物组能够改善炎性和坏死病理改变,对于CK、CK-MB及c Tn I的活性具有明显抑制作用。结论 K-Cox B-JN复方提取物对病毒性心肌炎小鼠心肌具有保护作用。Objective To discuss the myocardial protection about viral myocarditis mice induced by adriamycin( ADM) about compound extracting from againsting coxsackie virus B viral myocarditis capsule( K-Cox B-JN). Methods To observe the influence from myocardial tissue pathology,index of the mice hearts and spleens,CK,CK-MB,c Tn I through different groups from compound extracting. Results The group of compound flavonoids and the group of( flavonoids + saponins) improved the inflammatory pathological changes,and controlled the activity about CK,CK-MB and c Tn I. Conclusions K-Cox B-JN compound extracting could protect myocardial cells on viral myocarditis in mice.

关 键 词：K-Cox B-JN复方提取物 病毒性心肌炎 CK CK-MB CTNI 

分 类 号：R285.5[医药卫生—中药学]