T淋巴细胞免疫球蛋白黏蛋白-3与鼻息肉的相关性研究  

Study on the relationship of T cell immunoglobulin and mucin 3 and nasal polyps

作　　者：张飞[1] 夏立军[1] 

机构地区：[1]山西医科大学第一医院耳鼻咽喉头颈外科,太原030001

出　　处：《中华临床医师杂志（电子版）》2017年第5期845-848,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：鼻息肉是耳鼻咽喉科常见的以鼻腔-鼻窦黏膜为主的慢性炎症疾病,目前其病因和发病机制尚未完全明确。既往研究证实T淋巴细胞免疫球蛋白黏蛋白-3(TIM-3)可促进Tregs的增殖,抑制Th1、Th17细胞的分化及其分泌细胞因子,在疾病中参与重要的免疫应答。Th1/Th2细胞、Th17/Treg细胞的失衡是近年来研究鼻息肉发生的重要因素,本文通过鼻息肉中TIM-3与Th1、Th17、Treg细胞的研究进行综述。Nasal polyps is a common chronic inflammatory disease in the otolaryngology,which is the dominant lesion in the nasal sinus and mucosa,nowadays the pathogenesis is still not fully researched.Previous research confirmed T cell immunoglobulin and mucin 3(TIM-3) could promote Treg cells proliferation and inhibit Th1 cells and Th17 cells differentiation as well as their secretion of cytokines,participating in the significant immune response in the disease.Recently,Th1/Th2 cells and Th17/Treg cells imbalances play the important role in nasal polyps.The paper illuminated the correlation of TIM-3 and Th1,Th17 Treg cells in in the nasal polyps.

关 键 词：鼻息肉 TH1细胞 TH17细胞 TREG细胞 T淋巴细胞免疫球蛋白黏蛋白-3 

分 类 号：R765[医药卫生—耳鼻咽喉科]