(2R,3R)-2,3-二甲氧基-1,1,4,4-四苯基-1,4-丁二醇的一种实用制备方法（英文）  

A practical approach to (2R,3R)-2,3-dimethoxy-1,1,4,4-tetraphenyl-1,4-diol

作　　者：胡晓允[1] 尹忠友 唐艳柳 吴腊梅[1] HU Xiaoyun;YIN Zhongyou;TANG Yanliu;WU Lamei(College of Chemistry and Materials,South-Central University for Nationalities,Wuhan 430074,China)

机构地区：[1]中南民族大学化学与材料科学学院,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2019年第1期22-26,共5页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金资助项目(21302233);湖北省自然科学基金资助项目(2012FFB07410);中央高校基本科研业务费专项资金资助项目(CZY18010)

摘　　要：基于(2R,3R)-1,1,4,4-四苯基丁四醇的区域选择性2,3-二甲基化反应,建立了一种制备C_2手性二醇即(2R,3R)-2,3-二甲氧基-1,1,4,4-四苯基-1,4-丁二醇的实用方法.结果表明:与文献相比,该合成避免了酸的使用,减少了多取代THF衍生物的生成,提高了产率,不仅是制备(2R,3R)-2,3-二甲氧基-1,1,4,4-四苯基-1,4-丁二醇的便捷方法,也为(2R,3R)-1,1,4,4-四取代丁四醇的区域选择性衍生化提供了重要信息.A practical approach to(2R,3R)-2,3-dimethoxy-1,1,4,4-tetraphenylbutane-1,4-diol,a C2 chiral diol,was developed based on highly regioselective 2,3-methylation of(2R,3R)-1,1,4,4-tetraphenylbutaneol with MeI/NaH. The results indicated that compared with the literature,this procedure avoided the treatment with acid,reduced the generation of poly-substituted THF derivative,and increased the yield. This report not only provided a practical approach to prepare(2R,3R)-2,3-dimethoxy-1,1,4,4-tetraphenylbutane-1,4-diol,but also presented a significant reference for the regioselective derivatization of(2R,3R)-1,1,4,4-tetra-substituted butanetetraols.

关 键 词：选择性甲基化 (2R 3R)-1 1 4 4-四苯基丁四醇 (2R 3R)-2 3-二甲氧基-1 1 4 4-四苯基-1 4-丁二醇 环醚化 

分 类 号：TQ243.4[化学工程—有机化工]