二[4-羟基-5,6-二氢-6-烷基(芳基)-2H-吡喃-2-酮-3-]烃的合成及生物活性的研究  

Synthesis and Biological Activities of Bis[4-hydroxy-5,6-dihydro-6- alkyl(aryl)-2H-pyran-2-one-3-] methane

作　　者：李玉新[1] 王有名[2] 王素华[2] 杨小平[1] 李正名[2] 

机构地区：[1]湘潭师范学院化学系,湘潭411201 [2]南开大学元素有机化学研究所,元素有机化学重点实验室,天津300071

出　　处：《高等学校化学学报》2004年第2期281-283,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 983 2 0 5 0 )资助

摘　　要：采用 5 ,6-二氢 -6-烷基 (芳基 ) -2 H -吡喃 -2 ,4-二酮和醛进行缩合反应 ,合成了二 [4-羟基 -5 ,6-二氢 -6-烷基 (芳基 ) -2 H -吡喃 -2 -酮 -3 -]烃 .其结构经 1 H NMR和元素分析证实 .对反应条件 (反应温度、反应时间 )进行了探讨 .生物活性初步测定表明 。We attempted to build a carbon-carbon single bond in 3 position of 5,6-dihydro-6-alkyl(aryl)-2H-pyran-2,4-diones by Mannich reaction, but failed to gain the title compounds and the unexpected products were obtained. 5,6-Dihydro-6-alkyl(aryl)-2H-pyran-2,4-diones with aldehydes and a series of bis[4-hydroxy-5,6-dihydro-6-alkyl(aryl)-2H-pyran-2-one-3-] methanes were obtained. Their structures were confirmed by 1H NMR spectra and elemental analyses. In order to discuss this new condensation reaction, its reaction conditions were discussed. Compounds 3 were tested in vitro against many fungi such as P. Zeae, C. Arachidicala, P. Piricola, A. Solani, B. Cinerae, S. Sclerotiorum and H. Oryzae. The bioassay results show that they have some fungicidal tobacco virucidal activities.

关 键 词：二[4-羟基-5 6-二氢-6-烷基(芳基)-2H-吡喃-2-酮-3-]烃 合成 生物活性 5 6-二氢-6-烷基(芳基)-2H-吡喃-2 4-二酮 醛 缩合反应 生物活性 

分 类 号：TQ455.4[化学工程—农药化工]