氟罗沙星注射液稳定性及其有效期预测  

Stability study of fleroxacine injection and prediction of its expiry term

作　　者：王艳萍[1] 严晓鹏[1] 薛万俐[1] 史沛海[1] 

机构地区：[1]中国人民解放军第208医院,吉林长春130062

出　　处：《药学实践杂志》2004年第1期9-10,共2页Journal of Pharmaceutical Practice

摘　　要：目的 :考察氟罗沙星注射液的稳定性 ,并预测其室温贮存有效期。方法 :紫外分光光度法测定氟罗沙星注射液含量 ,用初均速法预测其有效期。结果 :本品在光照下色泽变深 ,含量明显变化 ,室温、高温条件下稳定。室温贮存有效期为 1.5年。结论 :初均速法预测氟罗沙星注射液有效期简便、迅速。Objective: To study statility of fleoxacin injection at room temperature as to predict its expiry term.Methods: The content of fleroxacin injection was determined by UV spectrophotometry,the expiry term was predicted by initial average rate methods.Result: The content of fleroxacine changed markedly and its color darkened when it was exposed to light.But it was stable when it was exposed to room temperature or high temperature.Expiry term predicted at room temperature is 1.5year.Conclusion: Initial average rate method is convenient and rapid.The fleroxacin injection should be keep in a dark place.

关 键 词：氟罗沙星注射液 稳定性 有效期 预测 喹诺酮类抗感染药 

分 类 号：R978.19[医药卫生—药品]