血栓素B_2及6-酮-前列腺素F_(1α)对糖尿病视网膜病变的诊断价值  

Diagnostic value of thromboxane B_2 and 6-prostaglandin F_(1α) levels in patients with diabetic retinopathy

作　　者：李永军[1] 郭秀瑾[2] 王长龄[2] 张玉华[3] 

机构地区：[1]河北医科大学第二医院检验科,河北石家庄050000 [2]河北医科大学第二医院眼科,河北石家庄050000 [3]河北医科大学第二医院核医学科,河北石家庄050000

出　　处：《临床荟萃》2004年第4期199-200,共2页Clinical Focus

摘　　要：目的　探讨血栓素B2 (thromboxaneB2 ,TXB2 )及 6 酮 前列腺素F1α(6 ketosteroid prostaglandinF1α,6 keto PGF1α)对糖尿病视网膜病变的诊断价值。方法　运用放射免疫方法对 35例糖尿病视网膜病变临床前期患者 ,36例糖尿病视网膜病变背景期患者 ,32例糖尿病视网膜病变增殖期患者以及 35例健康人进行TXB2 及 6 keto PGF1α的定量检测。结果　各期糖尿病视网膜病变患者的TXB2 及 6 keto PGF1α检测值与对照组比较差异有统计学意义 ,糖尿病视网膜病变临床前期、背景期及增殖期之间的TXB2 及 6 keto PGF1α水平亦显著不同。结论　检测糖尿病患者的TXB2 及 6 keto PGF1α水平对糖尿病视网膜病变的早期诊断具有重要意义。Objective To investigate diagnostic values of thromboxane B 2(TXB 2) and 6-ketosteroid-prostagland in F 1α(6-keto-PGF 1α) for patients with diabetic retinopathy. Methods TXB 2 and 6-keto-PGF 1α levels of 35 cases of diabetes without observable diabetic retinopathy (NDR);36 cases with background diabetic retinopathy (BDR);32 cases with proliferative diabetic retinopathy(PDR) and 35 cases of normal control were detected by radioimmunoassay(RIA). Results There were significantly differences in TXB 2 and 6-keto-PGF 1α levels between those of the normal control and retinopathy groups.Levels of TXB 2 and 6-keto-PGF 1α were significantly different among groups of NDR,BDR and PDR. Conclusion Detecting TXB 2 and 6-keto-PGF 1α is valuable for patients with diabetes in the early clinical diagnosis of diabetic retinopathy.

关 键 词：糖尿病视网膜病 血栓烷B2 前列腺素F类 

分 类 号：R587.2[医药卫生—内分泌]