埃博拉出血热的临床表现  

Clinical manifestation of Ebola hemorrhagic fever:a short review

作　　者：杜虹[1] 张颖[1] 王临旭[1] 李璟[1] 白雪帆[1] 连建奇[1] 

机构地区：[1]第四军医大学唐都医院传染病诊疗中心,西安710038

出　　处：《中国病毒病杂志》2015年第4期317-320,共4页Chinese Journal of Viral Diseases

基　　金：唐都医院科技创新发展基金重大临床研究项目(2013LCYJ002)

摘　　要：埃博拉出血热(Ebola hemorrhagic fever)是由埃博拉病毒(Ebola virus,EBOV)感染引起的致死率极高的急性病毒性传染病。2014年西非暴发的埃博拉出血热疫情的防控工作远未结束。由于采取了更为严密的个人防护及消毒隔离措施,医护人员可以近距离对患者的病情变化进行动态观察,对埃博拉出血热患者的临床观察研究也将不断深入。目前认为,EBOV侵入机体后。Ebola hemorrhagic fever is an acute communicable disease infected with Ebola virus(EBOV)at an extremely high fatality rate.The prevention and control of Ebola hemorrhagic fever endemic in West Africa region from 2014 is still ongoing.More rigorous measures for personnel protection,sterilization and isolation are required when taking care of Ebola patients and,medical staff could take dynamic and closer observations during clinical course of this disease for clinical signs and symptoms.More and more clinical study and observation on Ebola hemorrhagic fever are being reported to understand the pathophysiologic changes of this disease.Multiple organs and systems can be damaged in EBOV infection,especially liver,spleen and kidney.Fever,rash and thrombopenia are the three major specific manifestations of typical cases during the acute stage.Some patients infected with EBOV can be non-specific and with a mild course,recover in two weeks from onset of the illness gradually with leusemia,and the final diagnosis only depends on the specific serum detection.While some severe cases usually have complicated manifestations with fierce pathogenetic condition and poor prognosis.Because of the lack of specific therapy,some cases would die of fatal complications such as bleeding,acute renal failure and multiple organ dysfunction syndrome(MODS)within the first two weeks and the overall fatality rate can reach 50%-90%.

关 键 词：埃博拉出血热 埃博拉病毒 临床表现 

分 类 号：R512.8[医药卫生—内科学]