博尔纳病病毒流行病学研究进展  

Epidemiology of Borna disease virus:recent progress

作　　者：杨利玲[1] 徐平[1] 

机构地区：[1]遵义医学院第一附属医院,贵州遵义563000

出　　处：《中国病毒病杂志》2015年第5期392-395,共4页Chinese Journal of Viral Diseases

基　　金：国家自然科学基金(31160210)

摘　　要：博尔纳病(Borna disease,BD)最早发现于200多年前的德国,1855年在德国的萨克森州的Borna镇马群中暴发流行以精神行为异常为主的一种脑炎,导致大量的马匹死亡,其中还包括一个骑兵团的马匹,这一事件引起威廉二世皇帝的高度重视,故将本病以该镇的名字命名。20世纪初,有研究者从病马的脑组织中成功分离出病原体,并将病毒命名为博尔纳病病毒(Borna disease virus,Borna disease virus(BDV)belongs to negative stand RNA virus causing severe neurobehavioral diseases.Classical Borna disease is a progressive meningoencephalomyelitis in horse and sheep,known in central Europe.Most mammals including human beings have been found BDV infection.Human Borna disease with suspected neuropsychiatric is highly controversial.Recent detection of endogenized BDV-like genes in primate and other vertebrate genomes confirms that at least ancient bornaviruses did infect our ancestors.The epidemiology of BDV is still largely unknown.

关 键 词：博尔纳病病毒 流行病学 进展 

分 类 号：R373[医药卫生—病原生物学]