半夏泻心汤及其拆方对胃电节律失常大鼠胃肌间ICC含量的影响  

Effects of Banxiaxiexin Decoction on the Level of ICC in Stomach Myenteric Nerve Plexusin the Rats with Electrogastric Dysrhythmia

作　　者：李宇航[1] 王庆国[1] 杨美娟[1] 赵丽云[1] 陈萌[1] 李丽娜[1] 王丹[1] 张冬梅[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《北京中医药大学学报》2004年第1期21-23,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目 (No.3 0 2 715 75);教育部优秀青年教师资助计划项目 (No .2 0 0 2 40)

摘　　要：目的　拆方观察半夏泻心汤对胃电节律失常大鼠的影响 ,探讨该方“消痞散结”的作用机制及其组方配伍规律。方法　制备胃电节律失常大鼠模型 ,检测半夏泻心汤及其拆方对胃肌间神经丛c kit阳性ICC含量的影响。结果　半夏泻心汤及其拆方各组与模型组比较 ,均存在显著差异 (P <0 0 5 )。其中以辛苦组 (半夏、干姜、黄芩、黄连 )的效果最为显著。结论　半夏泻心汤及其拆方各组药物 ,均具有不同程度的调节胃肌间神经丛c kit阳性ICC含量的作用。辛苦组的作用最强 ,为进一步认识本方“苦降辛开 ,调畅气机”的作用机制 。Objective To observe the effects of Banxiaxiexin Decoction (BD) and the effects of its different of ingredient groups on the rats with electrogastric dysrhythmia, in order to investigate the mechanism of removing mass and dispersing the accumulation of the formula of BD and the rule of composition of the formula. Methods The rat model of electrogastric dysrhythmia was established for detecting the effects of BD and its different groups of ingredients on the level of c kit positive ICC in stomach myenteric nerve plexus. Results There were significant differences between the effects of BD and its different ingredient groups and those of the control ( P <0 05), especially between the effects of the pungent better ingredient group and the those of the control. Conclusion Both BD and its different ingredient groups can regulate the level of c kit positive ICC in stomach myenteric nerve plexus in varing degrees, and the pungent bitter ingredient group exerts the strongest effects. The results of the experiment can provide experimental evidence for further understanding the BD's mechanism of regulating the function of qi through bitter descending and pungent dispersing actions.

关 键 词：半夏泻心汤 胃肌间神经丛c-kit 阳性ICC含量 免疫组织化学 拆方研究 

分 类 号：R285.5[医药卫生—中药学]