pH依赖型肠安康胶囊的体外释药考察  

Investigation of the Drug Release of pH-Dependent Changankang Capsules in Vitro

作　　者：王玉蓉[1] 阎惠俊[1] 杨春梅[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《北京中医药大学学报》2004年第1期36-38,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家中医药管理局新药开发专项课题 (No .DIX 0 3 4A)

摘　　要：目的　对肠安康胶囊的pH依赖性进行体外释药考察。方法　以HPLC法测定盐酸小檗碱在人工胃液和人工肠液的含量为指标 ,对其pH依赖性做出体外释药初步评价。结果　肠安康胶囊采用丙烯酸树脂肠溶衣料处理 ,具有一定的延缓释药作用。在人工胃液中 1h后约释放药物 17%左右 ,在人工肠液中经 5h后基本释药完全。结论　肠安康胶囊的体外释药情况结果表明 ,本工艺是可行的 。Objective To study the pH dependence of Changankang Capsules (CC) through their drug release investigation in vitro.Methods HPLC method was used in the experiment, and the levels of berberine hydrochloride (BH) in the simulated gastric fluid (SGF) and the simulated intestinal fluid (SIF) were taken as the criteria to evaluate CC's pH dependent drug release in vitro.Results After being treated with the acrylic resin enteric coating, CC showed certain slow released action, with about a release of 17% in SGF after 1 hour, and with about a complete release in SIF after 5 hours. Conclusion The results of this experiment show that the technology of treating CC with acrylic resin enteric coating is feasible. It can be predicted that BH may be rich in the colon.

关 键 词：肠安康胶囊 盐酸小檗碱 高效液相色谱法 

分 类 号：R284.2[医药卫生—中药学]