2型糖尿病与冠心病患者血清可溶性细胞间粘附分子-1水平的比较  

Comparision of Serum Soluble Intercellular Adhension Molecules between Patients With Diabetes Mellitus And Patients With Coronary Heart Disease

作　　者：阮昱[1] 李霞[2] 张楠[1] 徐端珩[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院内分泌科,浙江杭州310016 [2]浙江大学医学院附属第一医院心内科

出　　处：《临床内科杂志》2004年第2期117-119,共3页Journal of Clinical Internal Medicine

摘　　要：目的　比较糖尿病与冠心病患者血清可溶性细胞间粘附分子 1(sICAM 1)及可溶性E 选择素 (sE s)水平 ,以探讨粘附分子在糖尿病大血管病变发生、发展中的作用。方法　采用酶联免疫吸附法 (ELISA)检测 61例 2型糖尿病 (糖尿病组 )和 5 8例冠心病 (冠心病组 )患者及 42名正常组 (对照组 )的血清sICAM 1、sE s水平 ,酶法检测血糖、血脂等。结果　糖尿病组与冠心病组sICAM 1及sE s水平均高于对照组 (P <0 .0 1) ,糖尿病组sICAM 1水平高于冠心病组 ,sICAM 1水平与总胆固醇、低密度脂蛋白胆固醇呈正相关。结论　ICAM 1及E s可能参与了糖尿病大血管病变及冠心病的发病机制 ,糖尿病具有高度的心血管疾病风险。血脂是影响sICAM 1水平的因素之一。Objective To measure and compare the serum sICAM-1 and sE-selectin in patients with diabetes mellitus and patients with coronary heart disease.Methods Determine the level of sICAM-1 and sE-s by ELISA in three groups(DM group,CHD group and normal control group ),measure the level of serum lipid and glucose.Results The level of sICAM-1 and sE-s in both group DM and group CHD were significantly higher than those in group NC,the serum sICAM-1 in group DM was significantly higher than that in group CHD(386.3±59.7vs344.1±63.2 P<0.05),the level of sICAM-1 was positively related to that of serum LDL and TC.Conclusion sICAM-1 and sE-s may involve in the pathogenesis of diabetic vascular complication and CHD,DM patients run high risks of cardiac vascular disease.Serum lipid have effect on the level of ICAM-1.

关 键 词：糖尿病 冠心病 细胞粘附分子 E.选择素 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]