早期补镁对心肌梗死再灌注时心肌顿抑的影响  

Effect of early magnesium infusion on reperfusion myocardial stunning after acute myocardial infarction

作　　者：施佳[1] 金惠根[1] 陈万春[1] 汪蔚青[1] 林银康[1] 欧少君[1] 尚孝堂[1] 江蓓湖[1] 

机构地区：[1]上海市普陀区中心医院心内科,200063

出　　处：《国外医学（心血管疾病分册）》2004年第1期49-51,共3页

摘　　要：目的:评价急性心肌梗死(AMI)早期补给硫酸镁对再灌注时心肌顿抑及梗死后左室收缩功能的影响。方法:将82例AMI患者随机分为硫酸镁干预组(n=42)和对照组(n=40),干预组在接受再灌注治疗前30min静脉给予25％硫酸镁20ml,两组均接受静脉溶栓或直接经皮冠脉介入治疗术(PCI)。再灌注成功的病例采用低剂量多巴酚丁胺超声负荷试验(LDDE)检测顿抑心肌的发生,并测定梗死后左室射血分数(LVEF)及左室收缩末期容量(LVESV)。结果:与对照组相比,硫酸镁干预组的顿抑心肌节段和梗死心肌节段较少(P<0.05),左室收缩功能优于对照组(P<0.05)。结论:AMI再灌注治疗同时早期补镁作为一种辅助治疗手段具有重要的意义。Objective:To evaluate the effect of early magnesium infusion on myocardial stunning and left ventricular systolic function after acute myocardial infarction( AMI). Methods:Eighty-two AMI patients were randomly dichotomized into magnesium intervention group(n = 42) and control group(n = 40). Twenty milliliter 25% magnesium sulphate were administered intravenously to paients in magnesium intervention group,all patients receiving either intravenous thrombolytic therapy or percutaneous coronary intervention (PCI). In patients exhibited reperfusion,low dose dobutamine echocardiography(LDDE) was carried out to observe the appearance of myocardial stunning,at the same time LVEF and LVESV were determined. Results: Magnesium infusion yielded less stunning segment (P<0. 01) and infarction segment (P<0. 05). Left ventricular systolic function showed better than control. Conclusions: Early magnesium infusion could be a good complementary treatment in AMI.

关 键 词：补镁 心肌梗死 再灌注 心肌顿抑 硫酸镁 

分 类 号：R542.22[医药卫生—心血管疾病]