络活胶囊对高血压大鼠血浆肾上腺髓质素和组织因子途径抑制物的影响  

EFFECTS OF LUOHUO CAPSULE ON LEVELS OF ADM AND TFPI IN PLASMA OF HYPERTENSION RATS

作　　者：于向东[1] 周文泉[2] 崔玲[2] 鞠大宏[3] 王硕仁[4] 秦腊梅[4] 腾静如[3] 潘静华[3] 

机构地区：[1]首都医科大学宣武医院北京老年病研究中心,北京100053 [2]中国中医研究院西苑医院,北京100091 [3]中国中医研究院基础理论研究所,北京100007 [4]东直门医院中心实验室,北京100007

出　　处：《山东中医药大学学报》2004年第1期56-59,共4页Journal of Shandong University of Traditional Chinese Medicine

基　　金：中国中医研究院创新课题 (CX 0 0 11)

摘　　要：采用腹腔注射左旋硝基精氨酸造成的大鼠高血压模型 ,对络活胶囊的降压机制进行研究。模型组、对照组、络活 1、2、3组各组应用左旋硝基精氨酸后 1、2周 ,心率明显减慢。药后各用药组血压均有所下降 ,与用药前比较有明显差异 ;与模型组比较 ,也有显著性差异 (P <0 .0 1)。各用药组用药后心率明显加快 ,与药前比较均有显著性差异 (P <0 .0 1) ,用药后ADM水平均有所升高 ,与用药前比较无显著性差异 ,但有升高趋势。络活 2、3组和对照组的TFPI水平与空白组比较有明显差异 (P <0 .0 5 )。说明络活胶囊可以降低左旋硝基精氨酸造成的大鼠高血压 ,升高血浆ADM水平 。The objective of the experimental is to study the decompression mechanism of Luohuo capsule for hypertension model rats by injecting N ω-Nitro-L-Arginine(L-NNA) in abdominal cavity. The heart rate was slow in the model rats groups. The blood pressure was significantly decreased and the heart rate increased after having been perfused stomach with Luohuo capsule or Beijing Hypotensive No.0 in the control group, Luohuo 1 group, Luohuo 2 group and Luohuo 3 group(P<0.01). The ADM was increased which had no significance in the treatment groups and the control group, and TFPI was significantly decreased in the control group, Luohuo 2 group and Luohuo 3 group(P<0.01). It indicated that the hypertension model rats' blood pressure,and TFPI was significantly decreased, the ADM was increased after being given Luohuo capsule.

关 键 词：高血压病 高血压模型 络活胶囊 肾上腺髓质素 血浆组织因子途径抑制物 左旋硝基精氨酸 

分 类 号：R285.5[医药卫生—中药学]