血小板与法洛四联症根治术患者预后关系的初步探讨  

Relationship between Platelet and Prognosis of the Total Correction of Tetralogy of Fallot

作　　者：赵俊飞[1] 安琪[1] 

机构地区：[1]四川大学华西医院心血管外科,成都610041

出　　处：《中国胸心血管外科临床杂志》2015年第8期744-747,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金资助项目(81370349)~~

摘　　要：目的探讨血小板与法洛四联症根治术患者预后之间的关系。方法纳入2011~2014年于我院行法洛四联症根治术的0~6岁死亡患者作为死亡组,并根据年龄、性别配对选取存活患者作为存活组;死亡组共11例,其中男7例、女4例,年龄(18.6±16.4)个月。存活组共11例,其中男7例、女4例,年龄(19.4±16.7)个月。根据术后血小板计数,将患者分为高血小板组与低血小板组,高血小板组共11例,其中男6例、女5例;低血小板组共11例,其中男8例、女3例。比较组间临床效果差异。结果死亡组术后4 h血小板计数低于存活组,且差异有统计学意义(P<0.05),白介素-6(IL-6)、C-反应蛋白(CRP)高于存活组(P<0.05),高血小板组死亡率明显低于低血小板组(P<0.05)。结论血小板可能减轻法洛四联症根治术后炎症反应,从而发挥保护作用,降低死亡率。Objective To explore the relationship between platelet and prognosis of the total correction of tetralogy of Fallot(TOF).Methods We included 11 dead patients with TOF at age of 0-6 years as a death group between2011 and 2014 year.There were 7 male and 4 female patients at age of 18.6±16.4 months in the death group.We selected11 matched survival patients according to age,gender of the patients as a survival group.There were also 7 male and 4female patients at age of 19.4±16.7 months in the death group.The patients were divided into a high-platelet group and a low-platelet group.There were 6 male and 5 female patients in the high-platelet group.While there were 8 male and 3female patients in the low-platelet group.Inflammatory cytokine and mortality were compared between the two groups.Results Post-operative count of platelet in the death group was significantly lower than that in the live group,while post-operative interleukin-6(IL-6) and C reactive protein(CRP) were much higher than those in the death group(P<0.05).Mortality was higher in the low-platelet group than that in the high-platelet group(P<0.05).Conclusion Platelets may alleviate inflammatory response and reduce mortality,which played a great role of protection.

关 键 词：血小板 法洛四联症 预后 

分 类 号：R654.2[医药卫生—外科学]