载药微粒体外释药行为的灰色系统模拟  

Imitation of the release process of drug-loaded particles by grey system theory

作　　者：杨恺[1] 张筱丹[2] 郑保忠[2] 

机构地区：[1]云南民族大学物理与电子电气信息工程学院,云南昆明650031 [2]云南大学化学与材料工程学院,云南昆明650091

出　　处：《中国医药工业杂志》2004年第2期109-112,共4页Chinese Journal of Pharmaceuticals

基　　金：云南省科技攻关基金项目(2001NG33);云南省中青年学术和技术带头人后备人才项目(2000YP04)。

摘　　要：应用灰色系统理论GM(1,1)动态模型对微囊、纳米粒及纳米粒-微球复合体的体外释药行为进行了模拟,建立了数学模型,模拟值与实验数据的相对误差在允许范围内。表明可利用灰色系统理论模拟、预测长效载药微粒的释药行为。GM(1, 1) grey dynamic model was used to imitate the release behavior of drug-loaded microcapsules,nanoparticles and nanoparticle-microsphere composites. These models were established by experimental data, and relativeerrors between imitated and practical data were in the permissible range. So the release behavior of sustained-release drug-loaded particles could be imitated and predicted by using of the grey system theory .

关 键 词：微囊 纳米粒 纳米粒- 微球复合体 灰色系统 体外释药 数学模拟 综述 

分 类 号：R944.9[医药卫生—药剂学]