2例男性育性障碍患者的联会复合体分析  

Synaptonemal Complexes Analysis in Male Fertility Impairment in Two Men

作　　者：刘静宇[1] 王晓然 曾宪录[3] 宋运淳[1] 

机构地区：[1]武汉大学植物发育生物学教育部重点实验室 [2]南阳市计划生育研究所,南阳473000 [3]东北师范大学遗传与细胞研究所,长春130024

出　　处：《遗传》2004年第1期13-17,共5页Hereditas（Beijing)

基　　金：国家重点基础研究发展规划项目(G1999053902);河南省高校青年骨干教师资助计划项目(2001225073)~~

摘　　要：运用表面铺展联会复合体(synaptonemalcomplex,SC)的电镜技术对2例男性育性障碍患者的联会复合体进行分析,发现患者1的部分粗线期精母细胞(20%)中出现配对紊乱(一些SCs中间未完全配对,未配对区轴心出现增粗,类似性染色体配对行为;有些SC仅两端配对,形成很短的两段SC,中间大部分未配对,在未配对区出现断裂,似乎是一个三价体和单价体)现象,大部分细胞配对正常。患者2的几乎100%生精细胞被阻断在减数分裂的前期阶段,显示联会异常如SC粉碎化、SC侧生组分膨化等现象。该文对男性育性障碍的机理进行了讨论。Synaptonemal complexes (SCs) of male fertility impairment were analysed in two patiants.In case one,his testicular histology was normal and there were 20% abnormal pachytene spermatoeytes,showing unsynaptic and broken SCs.It resulted in spermatogensis with unbalanced chromosomes and pregnancy wastages.In case two,he had no sperms basically.G-banded chromosome analysis of lymphocytes showed normal chromosomal karyotype,but triple fragment,lateral element swelling and fragment breakages of SCs were observed in his spermatocytes.The mechanisms of infertility,impairment of fertility for the observed men were discussed in this paper.

关 键 词：联会复合体 男性育性障碍 精母细胞 配对紊乱 

分 类 号：R698.2[医药卫生—泌尿科学]