盐酸西部曲明对小鼠生殖力和着床前后胚胎发育的影响  

Effects on fertility and early embryonic development to implantation of Sibutramine hydrochloride in mice

作　　者：胡渝华[1] 庞定国[1] 漆波[1] 雷琪[1] 游山[1] 刘玉清[1] 

机构地区：[1]四川大学华西公共卫生学院卫生毒理研究室,四川成都610041

出　　处：《华西药学杂志》2004年第1期27-29,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的　评价减肥新药盐酸西部曲明对♀亲代动物的生殖毒性和受精卵着床前的发育毒性。方法　持续饮水内给药 ,♂小鼠交配前给药 8周并持续给药至交配成功处死之前 ;♀小鼠交配前给药 2周并持续给药至妊娠d6。设 32、2 83、0 .2 5mg·kg-1·d-13个剂量组及 1个阴性对照组 ,观察亲代动物的一般状况、交配、受孕和妊娠 ,胎仔的着床、存活、体长、体重、外观、内脏和骨骼畸形等检测指标。结果　除相当于人预期摄入量 12 8倍的高剂量引起了亲代雄鼠体重减轻外 ,亲代和子代小鼠均未见其他毒性反应。结论　未见盐酸西部曲明对亲代有生殖毒性和对子代有发育毒性。OBJECTIVE To better understand the effects of Sibutramine hydrochloride on fertility of parents and development of embryon in mice.METHODS Sibutramine hydrochloride was administrated with drinking water.A premating treatment period of 8 weeks for male and 2 weeks for female were done in mice.Treatment was continued throughout mating to termination of males and through implantation for female.The mice were divided into three test groups[32 (1/5 LD 50),2.83,0.25 mg·kg -1·d -1]and a control group.Assessment of health status,mating,conception and gestation in parent mice;and implantation,survival,body length and weight,and malformation in offsprings were conducted.RESULTS The body weight lose was observed in the male parent mice in the group of 32 mg·kg -1·d -1.No other toxic responses in the parent mice and offspring were observed.CONCLUSION No reproductive toxicity was found in the parent mice and developmental toxicity in offspring induced by Sibutramine hydrochloride.

关 键 词：盐酸西部曲明 小鼠 生殖力 着床前 胚胎发育 影响 着床后 

分 类 号：R965.2[医药卫生—药理学]