氮酮对班布特罗透皮吸收的促渗作用研究  

Permeation enhancing effect of Azone on the transdermal absorption of Bambuterol

作　　者：何威[1] 陈海燕[1] 

机构地区：[1]中国医科大学附属第一医院,辽宁沈阳110001

出　　处：《华西药学杂志》2004年第1期39-41,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的　研究班布特罗的经皮渗透性 ,并考察不同浓度的氮酮对其的影响。方法　以 30 %乙醇 -水溶液为接受液 ,采用Valia -Chien水平扩散池进行大鼠离体皮肤的渗透实验。结果　不同浓度的氮酮对班布特罗的促渗作用不同。结论　由t检验及SPSS曲线拟和的结果可知 ,氮酮对班布特罗透皮吸收的促进作用具有浓度依赖性 ,氮酮的最佳促渗浓度为 5 % ,增渗比ER为 8.5 8。OBJECTIVE To study the transdermal permeability of Bambuterol,and to investigate the effect of Azone in different concentrations.METHODS To take 30% ethanol-water solution as acceptor,make the permeability test on the off-body skins of rats in Valia-Chien level diffusion chamber.RESULTS Different concentrations of Azone were responsible for the different influences on permeation enhancement of Bambuterol.CONCLUSION From the results of t test and curves fitting it was known that promotion of transdermal absorption of Bambuterol is dependent on the conentration of Azone,and the best concentration of Azone is 5% and ER is 8.58.

关 键 词：氮酮 班布特罗 透皮吸收 促渗作用 

分 类 号：R94[医药卫生—药剂学]