紫外分光光度法测定苯妥英钠片的含量  

Determination of Phenytoin sodium in tablets by UV spectrophotometry

作　　者：蒲其松[1] 吴体成[2] 张丽波[3] 

机构地区：[1]川北医学院药理教研室,四川南充637000 [2]巴中市人民医院药剂科,四川巴中675000 [3]川北医学院附属医院药剂科,四川南充637000

出　　处：《华西药学杂志》2004年第1期73-74,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的　测定苯妥英钠片的含量。方法　采用紫外分光光度法 ,以 0 .0 5mol·L-1NaOH为溶剂 ,在 2 12nm处测定。结果　苯妥英钠浓度在 3～ 15mg·L-1范围内线性关系良好 (r =0 .9998) ,平均回收率为 10 0 .2 % (n =5 ) ,RSD =0 .76 %。结论　所建立的方法简便、灵敏、准确 ,可供苯妥英钠片的含量测定。OBJECTIVE To establish an UV method to determine Phenytoin sodium in tablets.METHODS Phenytoin sodium was determined at 212 nm with 0.05 mol·L -1 NaOH as the solvents. RESULTS There was a good linear relationship between concentration and absorbance within the range of 3-15 mg·L -1 (r = 0.9998). The average recovery was 100.2% (n=5,RSD of 0.76%).CONCLUSION The method was simple, sensitive and accurate. It was suitable for measuring the contents of Phenytoin sodium in the tablets.

关 键 词：紫外分光光度法 测定 苯妥英钠片 含量 

分 类 号：R927.2[医药卫生—药学]