黄蜈散浸剂抗微生物作用的实验研究  

Experimental Studies of the Effects of Huang Wu San(黄吴散)on Microbial Growth and Viral Infections

作　　者：王言贵[1] 陈向伟[1] 于载畿[2] 魏育林 

机构地区：[1]山西医学院微生物教研室 [2]山西医学院妇产科教研室

出　　处：《中国中西医结合杂志》1985年第4期237-237,197,共2页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：黄蜈散浸剂是临床上用于治疗宫颈糜烂(简称宫糜)的一种有效制剂,为了解其有效作用,选与宫糜发生有关的微生物做了下面实验。一、黄蜈散浸剂(简称黄剂)对单纯疱疹病毒Ⅱ型(简称 HSV-2)致细胞病变作用的影响材料:黄剂的制备,取黄柏粗粉300g,捣碎的蜈蚣28g,加60%乙醇溶液3,000ml 浸泡48小时。The effects of Huang Wu San(HWS),a medicine used in the treatment of cervical erosion with good results, against microbial growth in vitro and on experimental viral infections in vivo were investigated. HWS was found to be active in anti-herpes simplex virus type-2(HSV-2).The survival of mice infected with HSV-2 was increased by the administration of HWS.The fatality rate of the treatment group was 40.0%,noticeably lower than that of the control group(86.7%,P<0.05).The antiviral activity of HWS on HSV-2 was also observed in vitro and the virucidal index of HWS reached the value of 166.0 or more. On the other hand,HWS showed a relatively broad antimicrobial spectrum,inhibiting vaginal microflora including Escherichia coli,Proteus vulgaris,Alcaligenes faecalis,Lactobacillus coprophilus,Clostridium butyricum, Staphylococcus aureus,β-Streptococcus and Candida albicans.The significance of these findings was discussed briefly.

关 键 词：简称 致细胞病变 微生物 金黄色葡萄球菌 单纯疤疹病毒 常见菌 HSV 致病菌 病原微生物 链球菌 小白鼠 

分 类 号：R2[医药卫生—中医学]