维司力农对大鼠缺血再灌注心肌的保护作用  

Protective Effect of Vesnarinone on Myocardial Induced by Ischemia and Reperfusion in Rats

作　　者：谢文利[1] 李宏捷[2] 朱江[1] 

机构地区：[1]武警医学院药理教研室,天津300162 [2]天津医科大学口腔病理教研室

出　　处：《天津医药》2004年第2期98-100,共3页Tianjin Medical Journal

摘　　要：目的 :研究维司力农对大鼠缺血再灌注心肌的保护作用。方法:将35只Wistar大鼠随机分为维司力农高、低剂量治疗组 (2mg/kg、1mg/kg)、二甲亚砜对照组、手术对照组、假手术组 (正常对照组 )。大鼠心肌缺血前10min给予相应药物 ,缺血30min再灌注2h后观察维司力农对大鼠心功能、乳酸脱氢酶 (LDH)活性、心肌梗死范围等的影响。结果:高、低剂量维司力农均能改善心肌梗死后大鼠的心功能,与二甲亚砜对照组和手术对照组比较 ,维司力农使心肌缺血大鼠的左室收缩压 (LVSP)、左室压最大上升速率 (dp/dtmax)、左室压最大下降速率 (-dp/dtmax)显著提高(P<0.01) ,心肌梗死范围显著减小 ,提高梗死后心肌LDH的活性(P<0.05)。Objective:To study the protective effects of vesnarinone on myoc ardial ischemia.Methods:Thirˉty_five Wistar rats were randomly divided into higher vesnarinone(2mg/kg),lower vesnarinone(1mg/kg),DMSO control,operation control and normal control groups.The effects of vesnarinone on myocardial function,activity of LDH and square of infarction were observed after ischemia for30minutes and reperfusion for2hours.Results:Vesnarinone1mg/kg and2mg/kg could markedly improve the myocardial function after myˉocardial infarction.Compared with DMSO control and operation control,vesnarinone could increase LVSP,dp/dt max ,and-dp/dt max (P<0.01),decrease the myocardial infarctional area,and increase the activity of LDH(P<0.05).Conclusion:Vesnarinone has a protective effect against myocardial ischemia.

关 键 词：维司力农 大鼠 心肌缺血 再灌注损伤 心肌保护 强心药 

分 类 号：R542.2[医药卫生—心血管疾病] R972.1[医药卫生—内科学]