紫杉醇两亲嵌段共聚物纳米囊的研究  

Studies on paclitaxel-loaded nanoparticles of amphiphilic block copolymer

作　　者：董岸杰[1] 邓联东[1] 孙多先[1] 张跃庭[1] 靳建洲[1] 元英进[1] 

机构地区：[1]天津大学化工学院,天津300072

出　　处：《药学学报》2004年第2期149-152,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 ( 30 1 70 2 2 7)

摘　　要：目的　探讨负载紫杉醇的聚乙二醇 b 聚 (D ,L 乳酸 )两亲性嵌段共聚物核 壳型纳米囊 (PMT)。方法　采用固相分散法制备PMT ,动态光散射 (DLS)测定PMT的粒径 ,透射电子显微镜 (TEM)和 1HNMR表征PMT的形态 ,研究共聚物相对分子质量和紫杉醇投药量对PMT的影响 ,考察PMT对昆明鼠肝癌H2 2的疗效。结果　PMT呈核 壳结构球形 ,粒径为纳米级 ,随着PEDLLA中疏水嵌段相对分子质量或载药量的增大而增大 ,PMT具有与Taxol类似的抑制肿瘤作用。Aim To investigate the paclitaxel-loaded nanoparticles of poly(ethylene glycol)-b -poly(D,L-lactic acid) amphiphilic diblock copolymer (PMT). Methods PMT was prepared by solid dispersion technique. The average size and size distri bution were determined by dynamic light scattering (DLS). The morphology was cha racterized by transmission electron microscopy (TEM) and 1HNMR . The in fluences of the copolymer molecular weight and the paclitaxel-fed amount on PMT were studied. Therapeutic effect of PMT was studied on Kunming mice liver cance r H22. Results PMT showed nanometer size and spherical morphology with core and shell. The size s of PMT increased with increasing the molecular weight of the hydrophobic segment in PEDLLA or increasing the drug-loaded amount. The tumour inhibiting effect of PMT was similar with that of Taxol. Conclusion It will provide an experiment basis for the development of new kind of intraveno us administration of paclitaxel.

关 键 词：紫杉醇 抗癌药物 纳米囊 聚乙二醇 聚乳酸 固相分散法 

分 类 号：R979.1[医药卫生—药品]