血浆肾素-血管紧张素系统、一氧化氮在心包炎中的变化及作用  

The changes and effect of plasma renin-angiotensin system and nitric oxide in rabbits pericarditis

作　　者：张小宁[1] 褚先秋[1] 李志梅[2] 张新英[3] 郭瑞珍[4] 

机构地区：[1]遵义医学院外科教研室 [2]遵义医学院药理教研室,贵州遵义563003 [3]遵义医学院附属医院核医学科,贵州遵义563003 [4]遵义医学院附属医院核病理科,贵州遵义563003

出　　处：《中国胸心血管外科临床杂志》2004年第1期56-58,共3页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：目的　探讨血浆肾素 -血管紧张素系统 (RAS)、一氧化氮 (NO)在心包炎病变过程中的变化及作用。方法　 2 1只雄性家兔随机分为两组 ,实验组 :11只 ,心包腔内注入 4 0 %尿素 ,2 ml/ kg;对照组 :10只 ,心包腔内注入等量生理盐水。分别于术前和术后 1、4、7、10、15、2 1天采血测定血浆肾素活性 (RA)、血管紧张素 (ANG )和 NO的浓度 ,观察心包、心肌、肺和肝的病理改变。　结果　术后实验组血浆 RA、ANG 和 NO浓度较术前均升高 ,术后 7～ 2 1天与对照组同时点比较差别具有显著性意义 (P<0 .0 1) ;实验组兔心包增生增厚、心肌变性、肺淤血和肝淤血。　结论心包炎病变过程中血浆 RAS、NO浓度均升高 ,一方面 NO与 RAS相拮抗 ,另一方面 NO和 RAS共同介导心包、心肌、肺、肝等器官的损伤。Objective To explore the changes and effect of plasma renin-angiotensin system (RAS) and nitric oxide (NO) in rabbits pericarditis. Methods Twenty-one male rabbits were divided into two groups randomly. Experimental group: 11 rabbits were injected 40% urea (2ml/kg) into pericardial cavity, control group: 10 rabbits were injected 0.9% natrium chloride into the pericardial cavity . The concentration of plasma renin active (RA), angiotensin Ⅱ(ANGⅡ) and NO were measured before operation and after operation 1,4,7,10,15,21 days. The histopathological changes of pericardium, myocardium, lung and liver were observed in the adopted specimens. Results The concentration of plasma RA, ANGⅡ and NO in experimental group increased after operation and significantly increased at 7 to 21 day compared with those in control group (P<0.01). In the experimental group, there were proliferation and thickening of pericardium, myocardial degeration, pulmonary ecchymosis and hepatic ecchymosis. Conclusion The concentration of plasma RAS and NO is increased in rabbits with pericarditis, plasma NO rejects the roles of RAS, NO and RAS lead to organs injury of pericardium, myocardium, lung, liver and so on.

关 键 词：血浆 肾素—血管紧张素系统 一氧化氮 心包炎 病理机制 动物模型 

分 类 号：R542.11[医药卫生—心血管疾病]