具有促微管聚合活性的海洋天然产物  

Marine natural products with activity of promoting microtubule assembly

作　　者：林厚文[1] 王增蕾[1] 刘皋林[1] 王旭东 张纯[1] 沈阳[1] 

机构地区：[1]第二军医大学长征医院药学部海洋药物实验室,上海200003 [2]解放军四二五医院药械科,海南三亚572008

出　　处：《中国海洋药物》2004年第1期42-45,共4页Chinese Journal of Marine Drugs

基　　金：国家高技术研究发展计划"86 3"资助课题 (2 0 0 2AA6 2 81 6 0 ) ;上海市青年科技启明星计划资助课题 (0 2QB1 4 0 0 3)

摘　　要：微管稳定剂在抗肿瘤药物的发现和发展中起着越来越重要的作用。对海洋中发现的具有促微管聚合活性的天然产物的研究进展进行综述 。Microtubule stabilizing agents continue to play an important role in anti tumor drugs discovery and development. The research advances in marine natural products with activity of promoting microtubule assembly were reviewed in this article. Difficulties and prospects of studying in this field were also discussed.

关 键 词：微管 微管蛋白 稳定剂 海洋天然产物 

分 类 号：R931.77[医药卫生—生药学] R979.1[医药卫生—药学]