新微生物农药抑霉菌素的研究  

STUDY ON A NEW ANTIFUNGAL ANTIBIOTIC, YIMEIMYCIN——ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL ACTIVITIES

作　　者：施跃峰[1] 桑金隆[1] 竺利红[1] 李孝辉[1] 吴吉安[1] 

机构地区：[1]浙江省农业科学院植物保护与微生物研究所,浙江杭州310021

出　　处：《核农学报》2004年第1期68-71,共4页Journal of Nuclear Agricultural Sciences

摘　　要：抑霉菌素产生菌经形态学特征及生理生化特性等分类学研究 ,定名为刺孢吸水链霉菌天目山亚种。主要活性组分经UV、HNMR、DEPTCNMR及H HCOSY等光谱分析 ,推知其化学结构系一新的核苷类抗生素。采用二倍稀释法对其展开体外抗菌活性研究 ,结果表明抑霉菌素对单丝壳菌、担子菌。Strain HA-8416,the producer of yimeimycin, was isolated from a soil sample collected in Hangzhou, Zhejiang province, China. Based on the investigation of morphological, cultural, physiological and biochemical characteristics as well as the cell wall chemical composition, strain HA-8416 is extremely similar to Streptomyces. hygrospinosus SF-104 , and named Streptomyces hygrospinosus var tianmushanensis n.var.Sang et al. By means of spectroscopic analysis (UV, 1H-NMR, DEPT CNMR and H-H COSY) , yimeimycin was identified as a new antibiotic of the nucleoside family. Yimeimycin appeared no activities against G+/G-bacteria, but was active against the fungi, Sphaerotheac cucurbitae, Pellicularia sasakii, Colletotrichum orbiculare, especially.

关 键 词：微生物农药 抑霉菌素 刺孢吸水链霉菌天目山亚种 核苷类抗生素 体外抗菌活性 

分 类 号：S482.2[农业科学—农药学]