愈疡散对大鼠实验性胃溃疡愈合质量的影响  

Effect of Yuyang Pulvis on QOUH in Treating the Gastric Ulcer Rats

作　　者：周志刚[1] 姜国平[1] 范慧珍 

机构地区：[1]江西中医学院,南昌330006 [2]江西省宜春市人民医院,宜春350008

出　　处：《江西中医学院学报》2004年第1期60-62,共3页Journal of Jiangxi College of Traditional Chinese Medicine

摘　　要：目的 :探讨中医古方愈疡散对大鼠实验性胃溃疡愈合质量的影响。方法 :用冰醋酸法制备大鼠慢性胃溃疡模型 ,设空白对照组、假手术组、西药对照组、愈疡散大剂量组、愈疡散小剂量组、胃溃疡模型组 ,共六组。实验结束后 ,用苏木精 -伊红染色 ,并对大鼠再生胃粘膜厚度进行观察 ,严格按照 6 酮 前列腺素F1α的试剂盒说明检测大鼠血浆中的 6 酮 前列腺素F1α的含量变化。结果 :愈疡散大剂量组、小剂量组的再生胃粘膜厚度明显高于胃溃疡模型组 (P <0 0 5) ;愈疡散大剂量组、小剂量组血浆 6 酮 前列腺素F1α含量与空白对照组、假手术组的含量接近 ,无显著性差异 (P >0 0 5) ,明显高于胃溃疡模型组和西药对照组 (P <0 0 5)。结论Objective:To study the effect of Yuyang powder on QOUH in treating gastric ulcer rats Methods:The SD rats were made into gastric ulcer by glacial acetic The 60 SD rats randimly divided into six groups nameluy normal group,model group,Ranitidine group,low dosage Yuyang pulvis,high dosage Yuyang pulvis and fase operation group The model group and fase operation group were fed with NS The gastric ulcer model group was fed with nothing only water and food The Ranitidine group was fed with Ranitidine the gastric mucosas of the rats were observed by HE According to the indication of the reagent of 6 keto PGF 1α ,We test the serum 6 KETO PGF 1α of the rats Result:The high dosage Yuyang pulvis,low dosage Yuyang pulvis is significantly thicker than the model group in regeneration thickness of rat gastric mucosa There were no significant differetiation in rat mucosal thickness of regeneration As for the serum level of 6 keto PGF 1α :there were no significantly differetiation amog low dosage Yuyang pulvis,high dosage Yuyang pulvis,normal group,fase operation group the serum level of 6 keto PGF 1α in high dosage Yuying pluvis,low dosage Yuying pulvis were significantly higher than those in model group,ranitidine group Conclusion:the Chinese traditional group prescription 'yuyang' can improve the QOUH

关 键 词：愈疡散 大鼠 实验 胃溃疡 愈合质量 6-酮-前列腺素F1Α 

分 类 号：R259.731[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]