Discussion on Improvement of Toxicological Pathology Study  

作　　者：Ren Jin(Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, CAS, Shanghai 200031) 

出　　处：《Science Foundation in China》2003年第1期31-34,共4页中国科学基金（英文版）

摘　　要：Toxicological pathology plays a key role in drug safety assessment. To enhance the research level of toxicological pathology, the following stud-ies should be carried out urgently: setting up a standard operation procedure (SOP) for toxico-logical pathology assessment; emphasizing on immunotoxicology evaluation; adopting a new ex-periment model of replacement, featuring high speed and reliability; introducing new techniques and new models in toxicological mechanism re-search; and establishing a new appraisal system to screen innovative drug and rapid and high pre-cision methods for early security assessment, de-tection and measurement.Toxicological pathology plays a key role in drug safety assessment. To enhance the research level of toxicological pathology, the following studies should be carried out urgently: setting up a standard operation procedure (SOP) for toxicological pathology assessment; emphasizing on immunotoxicology evaluation; adopting a new experiment model of replacement, featuring high speed and reliability; introducing new techniques and new models in toxicological mechanism research; and establishing a new appraisal system to screen innovative drug and rapid and high precision methods for early security assessment, detection and measurement.

关 键 词：drag safety assessment toxicological pathology immunotoxicology evaluation short-term replacement model highthroughput toxicology 

分 类 号：R99[医药卫生—毒理学]