砷氟中毒综合征的临床研究  

A Clinical Study on the Syndrome of Arsenism and Fluorosis

作　　者：黄月珍[1] 钱戌春[1] 王国荃[2] 

机构地区：[1]新疆医学院第一附属医院皮肤科 [2]新疆医学院预防医学系环境卫生学教研室

出　　处：《新疆医学院学报》1992年第1期14-17,共4页

基　　金：国家自然科学基金

摘　　要：自1982年3月至1989年8月作者对65例砷氟中毒综合征患者进行了临床研究。患者均长期饮用含砷量为0.6mg/L、含氟量为3.45mg/L的井水后发病。本文提出患者均既有慢性砷中毒,又有慢性氟中毒的临床表现,是砷氟两种微量元素联合对机体危害所引起的一组症候群。并发现本组病例周围神经炎及心血管改变较单纯慢性砷中毒或单纯氟中毒的发生率为高。提出了砷氟中毒综合征的主要诊断指标:(1)长期饮用含高砷高氟的水;(2)具有慢性砷中毒的二个主要症状或其中之一,即砷角化和/或砷色素异常;(3)具有慢性氟中毒的二个主要症状、体征或其中之一,即氟斑牙和/或氟骨症的临床表现或X线表现。对本组病例的皮肤肿瘤及内脏肿瘤的发生率,作者以为目前尚难定论,迄今本组皮肤肿瘤发生率为7.7％,一例伴发食道Ⅱ级鳞癌。A. clinical study was made on 65 cases with the syndrome of arsenism and fluorosis (SAF) from March 1982 to August 1980. All the cases with this syndrome had drunk a well water containing arsenic 0.6 mg/L and fluorine 3.45 mg/L for a long period. The patients all had the clinical manifestations of both chronic arsenism and fluorosis. It was a kind of syndrome caused by the combined harmful effects of these two trace elements, arsenic and fluorine. Higher incidences of peripheral neuritis and cardiovascular changes were found in these patients than in that with single chronic arsenism or single fluoresis. The chief diagnestic criteria of the SAF were recommended as follow: (1) having drunk high arsenic and hign fluorine water for a long period, (2) having the two principal symptoms of chronic arsenism or one of them, arsenic keratesis and/ or arsenic dyspigmentation, (3) having the principal symptoms and/ or signs of chronic fluorosis, clinical or roentgenographic manifestations, of dental fluoresis and/ or cesteoflucresis. However, no final conclusion has yet been reached on the morbidity of both skin and visceral tamors in this series. The incidence of skin cancer was 7.7 percert and a patient complicating a grade Ⅱ squamous cell carcinoma of esophagus was found.

关 键 词：综合征 砷中毒 地方性 中毒 

分 类 号：R599.9[医药卫生—内科学]