2-[对-(二甲氨基)苯乙烯]碘化甲基吡啶对豚鼠离体子宫收缩反应的影响  

Effects of 2- [p- (Dimethylamino)styryl]-1-Methylpyridinum Iodide on Contractility of Isolated Guinea Pig Uterus

作　　者：依巴代提[1] 玛依努尔[1] 王晓雯[1] 王雪飞[1] 张克锦[1] 李志良[2] 

机构地区：[1]新疆医学院基础部药理学教研室 [2]新疆医学院药学系药化教研室

出　　处：《新疆医学院学报》1992年第3期165-168,共4页

基　　金：国家自然科学基金

摘　　要：2-[对-(二甲氨基)苯乙烯]碘化甲基吡啶(DSPM)及2-[对-(二甲氨基)苯乙烯]氯化甲基吡啶(DSPM-Cl)能减弱催产素对豚鼠离体子宫的收缩作用,其作用可被增加浴液中的Ca^(2+)浓度所减弱。Ca^(2+)累积量效曲线表明,DSPM与DSPM-Cl能使CaCl_2量效反应曲线右移,最大效应降低,呈非竞争性拮抗。其作用与维拉帕米(Ver)相似,提示DSPM与DSPM-Cl似为一钙拮抗剂。The contraction of isolated guinea pig uterus induced by oxytocin were markedly inhibited by 2-[p-(dimethylamino)styryl]-1-methylpyridinum iodide (DSPM) and 2-[p-(dimethylamino) styryl]-methylpyridinum chloride (DSPM-Cl). The depression was attenuated by addition of Ca^(2+) to the bath fluid. DSPM and DSPM-Cl, which shifted the cumulative dose-response curvets to the right and depressed the maximal responses to CaCl_2, acted as non-competitive antagonists. These results indicate that DSPM and DSPM-Cl are both effective Ca^(2+)-antagonists very similar to verapamil on isolated guinea pig uteri.

关 键 词：维拉帕米 催产素 豚鼠 离体子宫 

分 类 号：R965[医药卫生—药理学]