紫草浸膏固体分散物的制备及稳定性的研究  

Study on Preparation and Stability of the Solid Dispersion of Radix Arnebiae seu Lithospermi

作　　者：逄秀娟[1] 刘晓红[1] 崔福德[1] 孙长山[1] 

机构地区：[1]沈阳药科大学,辽宁沈阳110015

出　　处：《中成药》2001年第1期5-7,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :提高紫草浸膏主要有效成分的体外溶出度 ,进而提高体内的生物利用度。方法 :采用了固体分散技术制备了紫草浸膏固体分散物 ,并进行了X 射线衍射实验及稳定性实验。结果 :制备的固体分散物紫草浸膏的有效成分体外溶出速度有明显增加且稳定 ,无老化现象。结论Objective: To enhance the dissolution rate in vitro and bioavailability in vivo of the active components of extraction of Radix Arnebiae seu Lithospermi. Methods: Solid dispersion of extract of Radix Arnebiae seu Lithospermi were prepared with solid dispersion technology, X ray diffraction and stability experiments were also carried out. Results: The dissolution rates in vitro of the active components of extraction of Radix Arnebiae seu Lithospermi solid dispersion were obviously raised and stable, and the solid dispersion was not easy to age. Conclusion: The dissolution rate in vitro of the active components in Radix Arnebiae seu Lithospermi can be inproved greatly by the solid dispersion using PVP and HPMC as a carrier.

关 键 词：紫草 固体分散物 溶出度 稳定性 

分 类 号：R944.24[医药卫生—药剂学]